Other

Versiti Blood Research Institute Foundation, Inc.

Huiying Zhi

Peter J Newman

Sridhar Rao

Nanyan Zhang

A transgenic mouse comprising T30A, S32P, Q33L, N39D, and M470Q mutations in GPIIIa, as well as methods for making the transgenic mouse and methods for using the transgenic mouse to screen test compounds are described.

Murine model of fetal/neonatal alloimmune thrombocytopenia

Methods of creating cells expressing specific platelet alloantigens by combining gene editing techniques and cell culture differentiation or expansion techniques employing pluripotent cells, including the steps of transfecting pluripotent cells with a plasmid encoding one or more guide RNAs targeting within a platelet alloantigen target locus and a nuclease in the presence of an HDR repair oligo and culturing the resulting cells to expand their numbers or to create a differentiated cell type of interest.

Growing community of inventors

Brookfield, WI, United States of America

Huiying Zhi