Theravance, Inc.

Advanced Medicine, Inc.

Huiwei Wu

Thomas E Jenkins

Yu-Hua Ji

John R Jacobsen

Timothy J Church

Sabine Axt

Jennifer Bolton

J Kevin Judice

Witold Hruzewicz

The invention provides substituted phenol compounds and pharmaceutical compositions containing substituted phenol compounds which are useful for inducing or maintaining anesthesia or sedation in a mammal. This invention also provides methods for inducing or maintaining anesthesia or sedation in a mammal using substituted phenol compounds.

Substituted phenol compounds useful for anesthesia and sedation

Novel compounds, pharmaceutical compositions and methods are disclosed for producing local anesthesia of long-duration. The compounds of this invention are multibinding compounds that comprise from 2 to 10 ligands covalently attached to a linker or linkers, each ligand being capable of binding to a ligand binding site in a voltage-gated Na channel to modulate the biological processes/functions thereof.

Local anesthetic compounds and uses

Local anesthetic compounds

This invention provides novel quinazolinone compounds and pharmaceutically acceptable salts thereof, which are useful as local anesthetics. This invention also provides pharmaceutical compositions containing such compounds; methods for producing local anesthesia in a mammal using such compounds; and processes and intermediates useful for preparing such compounds.

Growing community of inventors

Foster City, CA, United States of America

Huiwei Wu