Boston University

Huishan Li

John T Ngo

Wilson W Wong

Elliot Parker Tague

Meng Lai Nicole Wong

Wilson Wai Chun Wong

Ahmad S Khalil

Divya Israni

The technology described herein is directed to CAR polypeptides and systems comprising repressible proteases. In combination with a specific protease inhibitor, the activity of said CAR polypeptides and systems and cells comprising them can be modulated. Also described herein are methods of using said CAR polypeptides and systems, for example to treat various diseases and disorders.

Chimeric antigen receptor (CAR) modulation

The technology described herein is directed to regulated synthetic gene expression systems. In one aspect described herein are synthetic transcription factors (synTFs) comprising a DNA binding domain, a transcriptional effector domain, and a regulator protein. In other aspects described herein are gene expression systems comprising said synTFs and methods of treating diseases and disorders using said synTFs.

Regulated synthetic gene expression systems

Growing community of inventors

Brookline, MA, United States of America

Huishan Li