Crage Medical Co., Limited

Carsgen Therapeutics Limited

Carsgen Therapeutics Co., Ltd.

Huawei Technologies Co., Limited

Huiping Gao

Zonghai Li

Hua Jiang

Huamao Wang

Bizhi Shi

Peng Wang

Jianren Gu

Shengli Yang

Hongyang Wang

Zhimin Shi

Juan Kong

Kesang Li

Lan Duan

Disclosed herein are methods of treating a subject exhibiting a solid tumor that expresses Glypican-3 (GPC3). The methods typically utilize g GPC3 chimeric antigen receptor immunoresponsive cells to a subject in need thereof to effect killing of tumor cells.

Compositions and methods of cellular immunotherapy

Disclosed are an anti-CD19 humanized antibody prepared from a murine monoclonal antibody, a chimeric antigen receptor containing the humanized antibody, and an immune cell expressing the humanized antibody. Not only does the humanized antibody of the present invention not produce an anti-antibody response (AAR) and a human anti-mouse antibody response (HAMA), but same also has better affinity than a murine antibody, and has excellent activity and safety, thereby providing a new means for treating CD19-expressing tumors.

Anti-CD19 humanized antibody and immune effector cell targeting cd 19

A nucleic acid encoding a chimeric antigen receptor expressed at surface of a T lymphocyte, said chimeric antigen receptor comprises, connected in the order of, an extracellular binding domain, a transmembrane region, and an intracellular signaling domain, wherein the extracellular binding domain comprises a single chain antibody, scFv(GPC3), which specifically recognizes the C-terminal epitope of GPC3. A genetically modified T lymphocyte having a chimeric antigen receptor expressed at surface thereof, and the chimeric antigen receptor is expressed by the nucleic acid described above.

Chimeric antigen receptors targeting GPC3 and uses thereof

A nucleic acid for coding a chimeric antigen receptor protein expressed on the surface of a human T lymphocyte. The chimeric antigen receptor protein comprises an extracellular binding domain, a transmembrane domain and an intracellular signal domain that are orderly connected. The extracellular binding domain comprises a single-chain antibody scFv (EGFR) for specific recognition of 287to 302amino acid epitopes of a human epidermal growth factor receptor (EGFR).

Nucleic acids encoding chimeric antigen receptor proteins which bind epidermal growth factor receptor and T lymphocyte expressing the protein

Multi-functional antibody polypeptide comprises:

Multi-functional antibody polypeptide for cryptic epitope of epidermal growth factor receptor and T cell antigen

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Shanghai, China

Huiping Gao