Bristol-myers Squibb Compnay

Huiming Li

Alan J Korman

Mark J Selby

Guodong Chen

Michelle Minhua Han

Richard Y Huang

Haichun Huang

Mohan Srinivasan

Nils Lonberg

Changyu Wang

Karla Ann Henning

Indrani Chakraborty

Susan Wong

Paul O Sheppard

Brigitte Devaux

Ekaterina G Deyanova

Xiao Min Schebye

Christine Bee

Daniel F Ardourel

Andy X Deng

Anan Chuntharapai

Michelle Renee Kuhne

Hong-An Truong

Susan Chien-Szu Wong

Xi-Tao Wang

Anne C Lewin

Olufemi A Adelakun

Arvind Rajpal

Aaron Paul Yamniuk

Bryan C Barnhart

Ming Lei

Richard Yu-Cheng Huang

Liang Schweizer

Sandra V Hatcher

Hong-An Troung

Michelle Kuhne

Provided herein are antibodies, or antigen-binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen-binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen-binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen-binding portions thereof.

Antibodies against TIM3 and uses thereof

Provided herein are antibodies, or antigen binding portions thereof, that bind to T-cell immunoglobulin and mucin-domain containing-3 (TIM3) protein. Also provided are uses of these antibodies, or antigen binding portions thereof, in therapeutic applications, such as treatment of cancer. Further provided are cells that produce the antibodies, or antigen binding portions thereof, polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof, and vectors comprising the polynucleotides encoding the heavy and/or light chain regions of the antibodies, or antigen binding portions thereof.

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR) and uses thereof

Provided herein are diagnostic antibodies that bind to glucocorticoid-induced tumor necrosis factor receptor (GITR). Such antibodies are useful for methods of detecting the expression of GITR in biological samples, for example, tumor tissue, and identifying a cancer patient likely to respond to anti-GITR immunotherapy or predicting whether a cancer patient will respond to anti-GITR immunotherapy.

Anti-GITR antibodies for cancer diagnostics

Antibodies against glucocorticoid-induced tumor necrosis factor receptor (GITR)

Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.

Growing community of inventors

Lexington, MA, United States of America

Huiming Li