Pfizer Corporation

University of California

Boston Medical Center Corporation

Huilan Gao

Shaun R Coughlin

Nathan Higginson-Scott

Isaac J Rondon

Stefano V Gulla

Zong Sean Juo

Eric M Bennett

Stephen Berasi

Sreekumar R Kodangattil

David J Salant

Janet Elizabeth Buhlmann

Yun Cheol Kim

Lauren K Ely

Weining Lu

Xueping Fan

Christine Huard

Tovo David

Jian Li

Thomas Mikita

The invention provides antibodies, and antigen-binding fragments thereof, that specifically bind to ROBO2, as well as uses, and methods thereof.

Anti-ROBO2 antibodies, compositions, methods and uses thereof

In one aspect, antibodies, or antigen-binding fragments thereof, that specifically bind to activated Factor XI (FXIa) are provided. Also provided are methods of obtaining such antibodies and nucleic acids encoding the same. In another aspect, compositions and therapeutic prevention of thrombotic diseases, disorders or conditions are provided. In another aspect, anti-idiotype antibodies that bind anti-FXIa antibodies of the disclosure, as well as compositions comprising the anti-idiotype antibodies, methods of obtaining the antibodies and nucleic acids encoding the same, are also provided.

Antibodies to coagulation factor XIa and uses thereof

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West Roxbury, MA, United States of America

Huilan Gao