Zhejiang Hisun Pharmaceutical Co., Ltd.

Huijun Ren

Hua Bai

Linghui Zheng

Feng Chen

Hao Xu

Lingping Wang

Daochao Li

Xuexiao Ying

Fei Tang

Peijun Zhan

Jianhong Hu

Hongmei Fan

A fidaxomicin purification method, comprising: fermentingsp. HS-16-20 to generate fermented liquid; conducting solid/liquid separation on the fermented liquid, soaking mycelium in an organic solvent, and filtering to obtain a solution containing fidaxomicin; treating the solution with nanofiltration concentrate, and separating to obtain fidaxomicin crude product; conducting preparative column chromatography on the fidaxomicin crude product, eluting with an acid aqueous solution containing an organic solvent, and separating to obtain the refined fidaxomicin product.

Fidaxomicin purification method

A bacterial strain ofsp. and and the use thereof. The bacterial strain is namedsp. HS-16-20, whose preservation number is CGMCC (China General Microbiological Culture Collection Center) No. 7294. The bacterial strain can be used to generate Fidaxomicin or analogs thereof or compositions containing Fidaxomicin, such as by aerobically fermenting the strain in nutrient medium containing assimilable carbon and/or nitrogen sources. Fidaxomicin has an inhibitory effect on various gram positive bacteria pathogens, and in particular, on

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Huijun Ren