Case Western Reserve University

The Cleveland Clinic Foundation

The United States Government As Represented by the Department of Veterans Affairs

Parker-hannifin Corporation

Hui Zhu

Margot S Damaser

Steve Majerus

Swarup Bhunia

Zheng-Rong Lu

Zheng Han

Dennis Bourbeau

Robert Karam

Gino Banco

Ricardo Gonzalez

Bradley C Gill

Glenn R Craig

Joe Poliquin

Marie Lorentz

Daniel Greene

A sensing device can be used for ambulatory urodynamics. The sensing device can include an elongated outer housing constructed of flexible material that can curve within a patient's bladder. At least a portion of the outer housing can be filled with a non-compressible fluid. A flexible printed circuit board can be disposed within the outer housing to curve with the outer housing. The printed circuit board can include a pressure sensor, comprising a diaphragm, to collect pressure data; a microcontroller running control software; and a wireless transmitter to transmit the pressure data. A battery can be disposed within the outer housing and coupled to the printed circuit board. The flexible material of the outer housing is configured to be displaced by a pressure within the patient's bladder, the displacement is transmitted through the non-compressible fluid to the pressure sensor that provides the pressure data based on the displacement.

Sensing device for ambulatory urodynamics having a pressure sensitive housing

The present disclosure relates generally to using detected bladder events for the diagnosis of urinary incontinence or the treatment of lower urinary tract dysfunction. A system includes a sensing device comprising a pressure sensor to directly detect a pressure within a bladder. The sensing device is adapted to be located within the bladder. The system also includes a signal processing device to: receive a signal indicating the detected pressure within the bladder; detect a bladder event based the detected pressure within the signal; and characterize the bladder event as a bladder contraction event or a non-contraction event. The characterization of the bladder event can be used in the diagnosis of urinary incontinence or the treatment of lower urinary tract dysfunction.

Bladder event detection for diagnosis of urinary incontinence or treatment of lower urinary tract dysfunction

A compound includes at least one targeting peptide coupled to a detectable moiety. The targeting peptide binds to EDB-FN or EDA-FN and includes at least one of amino acid sequence selected from the group consisting of SEQ ID NOs: 1-30.

Targeting peptides and methods of use

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Pepper Pike, OH, United States of America

Hui Zhu