Element Biosciences, Inc.

Hui Zhen Mah

Michael Previte

Molly Min He

Matthew William Kellinger

Chunhong Zhou

Sinan Arslan

Lei Sun

Junhua Zhao

Lorenzo Berti

Steve Xiangling Chen

Minghao Guo

Leon Zilun Zhang

Multivalent binding compositions including a particle-nucleotide conjugate having a plurality of copies of a nucleotide attached to the particle are described. The multivalent binding compositions allow one to localize detectable signals to active regions of biochemical interaction, e.g., sites of protein-protein interaction, protein-nucleic acid interaction, nucleic acid hybridization, or enzymatic reaction, and can be used to identify sites of base incorporation in elongating nucleic acid chains during polymerase reactions and to provide improved base discrimination for sequencing and array based applications.

Multipart reagents having increased avidity for polymerase binding

Multivalent binding composition for nucleic acid analysis

Flow cell devices, cartridges, and systems are described that provide reduced manufacturing complexity, lowered consumable costs, and flexible system throughput for nucleic acid sequencing and other chemical or biological analysis applications. The flow cell device can include a capillary flow cell device or a microfluidic flow cell device.

Flow cell systems and devices

Growing community of inventors

San Diego, CA, United States of America

Hui Zhen Mah