Lifecell Corporation

Hui Xu

Hua Wan

Wenquan Sun

Li Ting Huang

Yi Heng Chen

Rick T Owens

Eric Stec

Sean Collins

Israel James Jessop

Nathaniel Bachrach

Ming F Pomerleau

Mrinal Shah

Carrie Fang

Edward S Griffey

Herbert Daniel Beniker

David J McQuillan

Darin Messina

Hui Li

Aaron M Barere

Dennis Lee

Kai-Roy Wang

Sangwook Park

Nimesh Kabaria

Joshua Czeczuga

Patrick Leamy

I-Chien Liao

Cunqi Cui

Israel Jessop

Jared Lombardi

Alexandra Pastino

Yi Chen

Cunqui Cui

Tissue product compositions and methods for treating a patient are provided. The tissue product composition may include a flowable carrier including a hyaluronic acid based material and acellular tissue matrix particles mixed within the carrier. Methods of producing the tissue product composition and an injection device filled with the tissue product composition are also provided.

Flowable acellular tissue matrix products and methods of production

The present application relates to use of transglutaminases to treat various products, including medical devices such as tissue grafts, tissue matrices or other tissue-derived materials, and synthetics. The transglutaminases can be applied to the medical devices to provide advantages such as adhesion resistance or abrasion resistance.

Transglutaminase treated products

The present disclosure provides tissue products produced from adipose tissues, as well as methods for producing such tissue products. The tissue products can include acellular tissue matrices for treatment of a breast.

Biologic breast implant

Tissue product compositions and methods for treating a patient are provided. The tissue product composition may include a flowable carrier including a hyaluronic acid based material and acellular tissue matrix particles mixed within the carrier. Methods of producing the tissue product composition and an injection device filled with the tissue product composition are also provided. Methods of treating a hand of a patient are also provided.

Methods for introduction of flowable acellular tissue matrix products into a hand

Compositions and methods for treating tissue are provided. The compositions may include tissue matrix derived from adipose tissue suitable for injection, small-volume implantation, or use as a soft-tissue regenerative material. Also provided are methods for producing such compositions.

Methods of treating tissue voids following removal of implantable infusion ports using adipose tissue products

Tissue compositions and methods of preparation thereof are provided. The tissue compositions can be used to treat or regenerate muscle tissue. The compositions can be configured to provide increased strength compared to other muscle matrices.

Devices including muscle matrix and methods of production and use

Adipose tissue products and methods of production

Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating select portions of a tissue matrix with a fluid containing at least one agent to produce a tissue matrix with variable mechanical and/or biological properties.

Methods for localized modification of tissue products

Disclosed herein are muscle implants and methods of making muscle implants comprising one or more decellularized muscle matrices. The muscle matrices can, optionally, be joined to one or more decellularized dermal matrices. The muscle implants can be used to enhance muscle volume or to treat muscle damage, defects, and/or disorders. The decellularized muscle matrices in the implants retain at least some of the myofibers found in a muscle tissue prior to processing.

Decellularized muscle matrix

Methods of forming a composition for treatment, compositions for treatment, and methods of treatment with the compositions are provided. The methods can include coating a synthetic material substrate with a biologic material. A portion of the biologic material can be acid-swelled.

Mesh compositions and methods of production

The present disclosure provides tissue products produced from extracellular tissue matrices. The tissue products can include acellular extracellular matrices including combinations of different tissue types. The combination can harness various properties of the different tissues to provide improved composite structures with desired mechanical and/or biologic properties.

Tissue matrices incorporating multiple tissue types

Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.

Natural tissue scaffolds as tissue fillers

A vascular graft for treatment of diseased or damaged blood vessels is disclosed. The graft comprises a sheet of acellular tissue matrix with an intact basement membrane. The graft is formed by wrapping the sheet into a tube and securing the edges of the sheet together. The acellular tissue matrix facilitates tissue ingrowth and remodeling of the graft with host cells.

Growing community of inventors

Plainsboro, NJ, United States of America

Hui Xu