Academia Sinica

Taipei Medical University

Hui-Wen Chang

Chia-Yu Chang

Yu-Chan Chao

Chia-Hwa Lee

Yuan-Soon Ho

Wei-Ting Hsu

Ching-Shyang Chen

Li-Ching Chen

Yu-Jia Chang

Po-Li Wei

Shih-Hsin Tu

Ying-Jan Wang

Ching-Shui Huang

Chih-Hsiung Wu

Shang-Te Danny Hsu

Ya-Chieh Chang

Chien-Hsi Chang

Disclosed herein is a recombinant antibody exhibiting binding affinity and/or neutralizing activity to porcine epidemic diarrhea virus (PEDV). According to some embodiments of the present disclosure, the PEDV is genotype 1 (G1) or genotype 2b (G2b) PEDV. Also disclosed herein are methods of diagnosing and treating PEDV infection by use of the present recombinant antibody.

Recombinant antibody and uses thereof

A baculovirus displaying a porcine epidemic diarrhea virus S protein or S1 domain thereof is provided for preventing porcine epidemic diarrhea virus infection.

Baculovirus and composition for detection and preventing of porcine epidemic diarrhea virus infection

The invention relates to methods of identifying a candidate compound which may inhibit estrogen receptor-dependent transcription or &#x3b1;9-nAChR overexpression and proliferation of nicotine-derived-compound-induced breast cancer cells by using an activating protein 1 (AP1) polypeptide. The invention found that &#x3b1;9-nAChR has an activating protein 1 (AP1)-binding site, that the &#x3b1;9-nAChR promoter is located at the AP1-binding site, and that ERs specifically bind to the &#x3b1;9-nAChR promoter at the AP1-binding site, indicating that ER-induced &#x3b1;9-nAChR up-regulation plays a central role in the response to endogenous (E2) or exogenous (nicotine) stimulation.

Method of identifying a candidate compound which may inhibit &#x3b1;9-nAchR overexpression or estrogen receptor-dependent transcription in nicotine-derived-compound-induced breast cancer cells

Growing community of inventors

Taipei, Taiwan

Hui-Wen Chang