Veracyte, Inc.

Apple Inc.

Affymetrix, Inc.

John Wayne Cancer Institute

Htg Molecular Diagnostics, Inc.

Hui Wang

Darya Chudova

Giulia C Kennedy

Jonathan I Wilde

Eric T Wang

Moraima Pagan

Nusrat Rabbee

Bonnie H Anderson

John E Blume

Alan J Williams

Simon Cawley

Tyson Clark

Oleg Zaydman

Dave S B Hoon

Bruce Seligmann

Frank Lu

James Qiu

Krishna Maddula

Tom Vasicek

Bj Kerns

Christopher Roberts

Zhenquiang Lu

B J Kerns

Darya I Chudova

Dave SB Hoon

Justin Brown

The present invention relates to compositions and methods for molecular profiling and diagnostics for genetic disorders and cancer, including but not limited to gene expression product markers associated with cancer or genetic disorders. In particular, the present invention provides algorithms and methods of classifying cancer, for example, thyroid cancer, methods of determining molecular profiles, and methods of analyzing results to provide a diagnosis.

Methods for treatment of thyroid cancer

The present invention relates to compositions, kits, and methods for molecular profiling and cancer diagnostics, including but not limited to genomic DNA markers associated with cancer. In particular, the present invention provides molecular profiles associated with thyroid cancer, methods of determining molecular profiles, and methods of analyzing results to provide a diagnosis.

Methods for classification of tissue samples as positive or negative for cancer

System, method, and computer program product for partitioned data replication are described. A data replication system can partition a file stored on a primary storage device into multiple data blocks, and store an index mapping the blocks and the file. Initially, the system can replicate the file and the index to a secondary storage device. The data stored in the file can change after the initial replication. The system can determine which block among the data blocks has changed by updating the index and comparing the updated index with the original index. The system can then replicate the change by replicating only the changed block and the updated index to the secondary system.

Partitioned data replication

Methods and compositions for diagnosis of thyroid conditions

Algorithms for disease diagnostics

Representative embodiments set forth herein disclose techniques for enabling a client application to supplement its features by utilizing the functionalities provided by a web browser in a secure manner. According to some embodiments, the client application can authenticate with an authentication server to establish a trusted connection between the client application and the authentication server. In turn, the client application can issue a request to the authentication server for particular content. Next, the authentication server can establish a 'content uniform resource locator (URL)' for accessing the content, and interface with a web server to establish an 'authentication URL', and return both the content URL and the authentication URL to the client application. In turn, the client application invokes an instance of the web browser and causes the web browser to access the authentication URL to obtain session information, and subsequently access the content URL to obtain the content.

Techniques for providing authentication information to external and embedded web browsers

Methods and software products for analysis of alternative splicing are disclosed. In general the methods involve normalizing probe set or exon intensity to an expression level measurement of the gene. The methods may be used to identify tissue-specific alternative splicing events.

Methods and computer software for detecting splice variants

The present disorders disclosure provides method for processing or analyzing a sample of thyroid tissue of a subject, to generate a classification of the sample of thyroid tissue as positive or negative for thyroid cancer. The present disclosure also provides algorithms and methods of classifying cancer, for example, thyroid cancer, methods of determining molecular profiles, and methods of analyzing results, which may be used to provide a diagnosis.

Methods for processing or analyzing sample of thyroid tissue

Disclosed are methods for determining whether a melanocyte-containing sample (such as a nevus or other pigmented lesion) is benign or a primary melanoma. These methods can include detecting (at the molecular level, e.g., mRNA, miRNA, or protein) the expression of at least two disclosed genes in a biological sample obtained from a subject. Also provided are arrays and kits that can be used with the methods.

Molecular malignancy in melanocytic lesions

Methods, program products, and systems of intelligent data delivery and storage based on data characteristics are disclosed. A database server can receive, from a user device, a request for data. The database server can determine a data size and a data type of the requested data. The database server can identify, based on the data size and data type, and from multiple candidate data delivery protocols for responding to the request, a data delivery protocol designated for delivering data having the data size and data type. The database server can deliver the data to the user device in response to the request using the identified data delivery protocol.

Intelligent data delivery and storage based on data characteristics

The present invention relates to compositions, kits, and methods for molecular profiling and cancer diagnostics, including but not limited to gene expression product markers, alternative exon usage markers, and DNA polymorphisms associated with cancer. In particular, the present invention provides molecular profiles associated with thyroid cancer, methods of determining molecular profiles, and methods of analyzing results to provide a diagnosis.

Methods and compositions of molecular profiling for disease diagnostics

Growing community of inventors

San Bruno, CA, United States of America

Hui Wang