Amgen Inc.

Atara Biotherapeutics, Inc.

Hui-Quan Han

Xiaolan Zhou

Keith Soo-Nyung Kwak

Jeonghoon Sun

Lei-Ting Tony Tam

Keith Kwak

Qing Chen

John Lu

The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.

Variant activin receptor

Variant activin IIB receptor

The disclosure provides compositions and methods relating to or derived from anti-activin A binding proteins, including antibodies. In particular embodiments, the disclosure provides fully human, humanized, and chimeric anti-activin A antibodies that bind human activin A, activin A-binding fragments and derivatives of such antibodies, and activin A-binding polypeptides comprising such fragments. Other embodiments provide nucleic acids encoding such antibodies, antibody fragments and derivatives and polypeptides, cells comprising such polynucleotides, methods of making such antibodies, antibody fragments and derivatives and polypeptides, and methods of using such antibodies, antibody fragments and derivatives and polypeptides, including methods of treating or diagnosing subjects having activin A-related disorders or conditions including cachexia related to gonadal cancer, other cancers, rheumatoid arthritis, and other diseases.

Anti-activin a antibodies and uses thereof

Isolated nucleic acid molecules encoding variant activin receptor polypeptides

Variant activin receptor polypeptides and uses thereof

Anti-activin A antibodies and uses thereof

The present invention relates to a novel polypeptide encoding a protein which is the full length human ortholog of E3&#x3b1; ubiquitin ligase. The invention also relates to vector, host cells, antibodies and recombinant methods for producing the polypeptide. In addition, the invention discloses therapeutic, diagnostic and research utilities for these and related products.

Human E3&#x3b1; ubiquitin ligase family

Variant activin receptor polypeptides

The present invention relates to a novel polypeptide encoding a protein which is the full length human ortholog of E3&agr; ubiquitin ligase. The invention also relates to vector, host cells, antibodies and recombinant methods for producing the polypeptide. In addition, the invention discloses therapeutic, diagnostic and research utilities for these and related products.

Human E3&agr; ubiquitin ligase family

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Thousand Oaks, CA, United States of America

Hui-Quan Han