Dingfu Biotarget Co., Ltd.

Steering Solutions IP Holding Corporation

Shihuida Pharmaceutical Group (jilin) Co., Ltd.

Hui Ma

Jianjian Peng

Shilong Fu

Shuli Ma

Xiaolong Pan

Ting Xu

Xiaoxiao Wang

Yan Luan

Meng Zhao

Shanshan Ning

Yeqiong Fei

Shenbing (Assur) Wen

Kai Fu

Carl R Castanier

Brandon L Finney

Xin Zhang

Ace Jiang

Polen Li

Yuki Ye

Chao (Super) Liu

A bearing assembly system for a vehicle steering system includes a tubular member having a radially inwardly protruding shoulder, the tubular member having a stake portion angling radially inwardly, the stake portion having a stake surface. The bearing assembly system also includes a bearing disposed within the tubular member and in contact with the radially inwardly protruding shoulder. The bearing assembly system further includes a retainer disposed within the tubular member and in contact with the bearing, the bearing disposed between the retainer and the radially inwardly protruding shoulder, the retainer having an angled surface, the angled surface in flush contact with the stake surface in a fully assembled condition.

Bearing assembly system for vehicle steering systems

An I-shaft assembly includes an upper shaft extending along an axis between a first upper end and a first lower end bounding a first hollow bore. An intermediate shaft extends along the axis between a second upper end and a second lower end bounding a second hollow bore. The second upper end is disposed in the first hollow bore. A lower shaft extends along the axis between a third upper end and a third lower end disposed in the second hollow bore. The upper shaft is releasably fixed for controlled movement along the axis relative to the intermediate shaft, and the lower shaft is releasably fixed against movement along the axis relative to the intermediate shaft during a normal operating condition. The upper shaft moves along the axis relative to the intermediate shaft and the lower shaft moves along the axis relative to the intermediate shaft during an abnormal operating condition.

Three segment intermediated shaft

An antibody may be capable of specifically binding CD137 or an antigen binding fragment thereof, wherein the light chain variable region and the heavy chain variable region have one or more mutations. The antibody or antigen binding fragment thereof may be used in preparing a drug. The antibody or an antigen binding fragment thereof may specifically bind CD137, and may include a light chain variable region VL and a heavy chain variable region VH, wherein compared to a sequence as shown in SEQ ID NO: 103, the VL comprises one or more VL amino acid mutations, and the VL amino acid mutation occurs at one or more positions: V3, A10, K44, D71, and/or V77.

Anti-CD137 antibodies and method of treating colorectal cancer using them

The present disclosure provides proteinaceous complexes, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous complexes, methods for producing the proteinaceous complexes, and uses thereof.

IL-10 EGFR antibody fusion protein and uses thereof

Disclosed are a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof. a fully human monoclonal antibody specifically binding to a CD137 or an antigen binding portion thereof. On one hand, provided are a CDR/variable region sequence of the antibody and an encoding nucleic acid sequence thereof; on the other hand, provided is a method for treating diseases using the antibody or the antigen binding portion thereof.

Fully human antibody against human CD 137

The present application provides an anti-OX40 human antibody. In particular, a human antibody specifically binding to OX40 is obtained with yeast display screening, and the affinity of the antibody is improved with affinity maturation. The present application also provides a use of the antibody for the prevention or treatment of tumors.

Anti-OX40 antibody and application thereof

The present disclosure provides proteinaceous heterodimers, pharmaceutical compositions, medicaments and/or kits comprising the proteinaceous heterodimers, methods for producing the proteinaceous heterodimers, and uses thereof.

Proteinaceous heterodimer and use thereof

Growing community of inventors

Jiangsu, China

Hui Ma