Korea Atomic Energy Research Institute

Hui Jeong Gwon

Sang Hyun Park

Myung Woo Byun

Byung Chul Shin

Sun Ju Choi

Kyung Bae Park

Sang Mu Choi

Beom Su Jang

Woong Woo Park

Young Don Hong

Kwang Hee Han

Seung Ho Jang

Disclosed herein is a method for the preparation of radioisotope-labeled compounds using CNT. It comprises filling the carbon nanotube with a radioisotope; and labeling a physiologically active material with the radioisotope charged in the carbon nanotube. Taking advantage of CNT, the method can prepare a radioisotope-labeled compound invention at a high yield and in a simple manner. Also, the radioisotope, when remaining unreacted, can be recovered by the filtration of the CNT, thereby achieving the prevention of radioactive contamination and the reduction of radioactive waste. Further, the radioisotope-labeled compound is useful as a contrast medium for imaging the hepatobiliary system.

Preparation method of radioisotope labeling compound using carbon nanotube

Disclosed relates to an ionic liquid type crown ether derivative, expressed by Chemical Formula 1 below, for isolating metal ions, a method for preparing the same and a method for isolating selectively the metal ions using the cycle size of the same. The present invention can provide the ionic liquid type crown ether and isolate metal ions including radioactive isotopes efficiently using the same. Furthermore, the prevent invention provides crown ether valuably used as a recyclable and environment-friendly isolating medium by preparing crown ether of ionic liquid type.  wherein m, n, Xand R are identical with those in the description.

Ionic liquid type crown ether derivatives, method for preparing the same and method for isolating metal ions using the same

Disclosed relates to organic germanium nanocolloids, to which technetium-99m (Tc), a radionuclide, is labeled, method of the same, and a spleen-imaging agent including the same. According to the invention,Tc-labeled organic germanium nanocolloids having high labeling efficiency and stability can be provided. Moreover, since theTc-labeled organic germanium nanocolloids of the invention are accumulated in the spleen considerably higher than the conventional spleen-imaging agent, it is possible to use theTc-labeled organic germanium nanocolloids of the present invention as a therapeutic radiopharmaceutical for the spleen imaging.

Technetium-99m-labeled organic germanium nanocolloids, method of preparing the same and use thereof

A method for labelling a sulfide compound with technetium or rhenium, comprising the reaction of a disulfide compound with pertechnetate or perrhenate in the presence of borohydride exchange resin to obtain a complex of technetium or rhenium with the sulfide compound. The method can directly label disulfide compounds with technetium or rhenium, can skip the synthetic step of thiol-protected S-precursor, and is useful for high value-added radiopharmaceuticals.

Method for labelling technetium or rhenium using borohydride exchange resin

The present invention relates to a method of preparing technetium or rhenium complex for radiopharmaceuticals, through reaction of pertechnetate or perrhenate with a ligand in the presence of a reducing agent, wherein the reducing agent is a borohydride exchange resin (BER). The borohydride exchange resin of the present invention has advantages of being stable in a wide range of Ph, including acidic or alkaline condition(Ph 2&#x2dc;14) and thus being applicable to biological materials as well as being easily removable through filtration when being administrated. Also since the radiolabelled complex is produced under conditions milder than those required for the conventional reducing agents as well as has high radiochemical purity and high labeling efficiency, the conventional reducing agents can be replaced by the BER of the present invention.

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Daejeon, South Korea

Hui Jeong Gwon