Rigel Pharmaceuticals, Incorporated

Bristol-myers Squibb Compnay

Other

Bristol Meyers Squibb Company

Hui Hong

Rajinder Paul Singh

Ihab S Darwish

Jiaxin Yu

Xiang Xu

Sambaiah Thota

Somasekhar Bhamidipati

Ankush Argade

Jeffrey Clough

Robert Michael Borzilleri

Pingyu Ding

Todd M Kinsella

Upender Velaparthi

Jayakumar Sankara Warrier

Peiying Liu

Marina Gelman

Andy Atuegbu

Hasibur Rahaman

Chetan Padmakar Darne

Vadim Markovtosov

Dane A Goff

Rao Kolluri

Henry Lu

Vadim Markovtsov

Emily Stauffer

Chetan Padmakar Dame

Sambiah Thota

Eileen Goldstein

Disclosed are imidazole and thiazole compounds, as well as pharmaceutical compositions and methods of use thereof. One embodiment is a compound having the structure and pharmaceutically acceptable salts, prodrugs and N-oxides thereof (and solvates and hydrates thereof), wherein X, A, Z, Rand R' are as described herein. In certain embodiments, a compound disclosed herein inhibits TGF-&#x3b2;, and can be used to treat disease by blocking TGF-&#x3b2; signaling.

TGF-beta inhibitors

TGF-&#x3b2; inhibitors

This invention is directed to methods of treating diseases or conditions associated with JAK2 activity in a mammal comprising the administration of a compound of formula (I): where n, m, Y, R, R, R, Rand Rare disclosed herein, or a pharmaceutically acceptable salt.

Pyrimidine-2-amine compounds and their use as inhibitors of JAK kinases

Disclosed are carboxamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R, R, R, R, D, J, Z, T, p, q, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

Carboxamide compounds and methods for using the same

The present invention provides N-substituted-heterocycloalkyloxybenzamide compounds, as well as pharmaceutical compositions and methods of use. One embodiment of the invention is a compound having the structure in which R, R, R, R, T, n, w and x are as described herein. In certain embodiments of the invention, a compound of the present invention activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

N-substituted-heterocycloalkyloxybenzamide compounds and methods of use

Disclosed are carboxamide, sulfonamide and amine compounds including certain AMPK-activating piperidinylxoy-substituted 2,3-dihydro-1H-indene-1-amine compounds, as well as pharmaceutical compositions including them. One embodiment is a compound having the structure in which R, R,R,R,R,R,R, G, Q, k, v, x and y are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

AMPK-activating piperidinyloxy-substituted 2,3-dihydro-1H-indene-1-amine compounds and pharmaceutical compositions including the same

Disclosed are carboxamide, sulfonamide and amine compounds, as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R, R, R, D, E, J, T, p, q and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

Carboxamide, sulfonamide and amine compounds and methods for using the same

Disclosed are carboxamide compounds as well as pharmaceutical compositions and methods of use. One embodiment is a compound having the structure in which R, R, R, R, T, p, q, w and x are as described herein. In certain embodiments, a compound disclosed herein activates the AMPK pathway, and can be used to treat metabolism-related disorders and conditions.

This invention is directed to compounds of formula (I): where n, m, Y, R, R, R, Rand Rare disclosed herein, as isolated stereoisomers or mixtures thereof, or pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising the compounds of formula (I); and methods of using the compounds and the pharmaceutical compositions in treating diseases or conditions associated with JAK2 activity.

Growing community of inventors

Palo Alto, CA, United States of America

Hui Hong