Touchstone International Medical Science Co., Ltd.

Crystal Pharmaceutical (suzhou) Co., Ltd.

Hui Gao

Yanfeng Zhang

Minhua Chen

Xiaoyu Zhang

Wangdong Chen

Tuo Shu

Yanping Ye

Fei Lu

Yuhao Chen

A staple cartridge assembly comprises a connector, a cutter push rod and an elastic sheet, the elastic sheet having a first through groove and the cutter push rod being formed by laminating multiple sheets, wherein when the staple cartridge assembly is in an original status or a closed status, part of the cutter push rod is located in the first through groove, and the first through groove restricts detaching of the multiple sheets in a laminating direction of the multiple sheets; in a firing process of the staple cartridge assembly, the cutter push rod moves towards a distal end of the staple cartridge assembly to press the elastic sheet, such that the elastic sheet deforms and the cutter push rod is gradually detached from the first through groove; after the firing of the staple cartridge assembly is finished, the cutter push rod is detached from the first through groove.

Staple cartridge assembly and medical stapler using the staple cartridge assembly

The present disclosure relates to a novel crystalline form of Galunisertib, processes for preparation and use thereof. The present disclosure also relates to a pharmaceutical composition comprises the novel crystalline form of Galunisertib and use of the novel crystalline form of Galunisertib and pharmaceutical composition for preparing drugs treating disease. The crystalline form of the present disclosure has good stability, solubility and hygroscopicity, which has significant value for future drug optimization and development. 

Galunisertib crystalline form, preparation method thereof and use thereof

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Suzhou, China

Hui Gao