Mackay Memorial Hospital

Taipei Veterans General Hospital

National Chiayi University

Hui-Fen Liao

Yu-Jen Chen

Cheng-Deng Kuo

Jin-Yi Wu

Yu-Yawn Chen

Sue-Mei Liu

Tsung-Chung Lin

Novel N-substituted norcantharimide derivatives are disclosed herein. The novel N-substituted norcantharimide derivatives are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly for treating leukemia.

Lipophilic N-substituted norcantharimide derivatives and uses thereof

The present invention relates to a method of treating leukemia using rice prolamin, comprising administering a daily dose of isolated prolamin to a patient suffering from leukemia for a period of time from 5 days to 10 days. For the treatment application, the rice prolamin can stimulate human peripheral blood mononuclear cell (PBMC) to produce cytokines, such as tumor necrosis factor-alpha, to inhibit growth of and induce differentiation of human leukemia cells. The rice prolamin is gluten-free, thus will not trigger gastrointestinal allergic reaction, it also can decrease the tumor weight without changes in body weight and can inhibit the growth of peripheral blood leukocyte in leukemia mouse model.

Method of treating leukemia using rice prolamin

Novel Uses of small molecules, particularly, 6-methylsulfinylhexyl isothiocyanate and 6-methylsulfonylhexyl isothiocyanate, are disclosed herein. The two isothiocyanates are useful as lead compounds for manufacturing a medicament or a pharmaceutical composition for treating cancer, particularly drug-resistant cancer, in a patient.

Use of isothiocyanates for treating cancer

A nutraceutical composition containing 0.01-99% by weight polysaccharides enriched from an extract of beans of(L.) Merr. Also disclosed are a method of enriching polysaccharides from pulverized beans of(L.) Merr.; a polysaccharide having a backbone of &#x3b1;-(1,6)-linked glucose residues, and one or more galactose or mannose residues are bonded to the C-3 or C-4 position of one or more of the glucose residues by a (1,3)- or a (1,4)-linkage; and a method of treating a subject with such polysaccharides to increase blood cell counts.

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Chiayi, Taiwan

Hui-Fen Liao