The University of Texas System

Washington University

Hui Deng

Zhiqiang An

Ningyan Zhang

Philipp Erich Scherer

Rong Li

Xiujie Sun

Dawei Bu

The present disclosure relates to antibodies binding to tumor discoidin domain receptor 1 (DDR1) and the uses of the antibodies in detecting and treating cancer.

DDR1 antibodies and uses thereof

Aspects of the present invention relate to methods and reagents for increasing chemosensitivity to platinum-based chemotherapy. In one aspect, a method of increasing chemosensitivity to platinum-based chemotherapy is provided, comprising administering to a patient in need thereof an effective amount of an endotrophin-neutralizing agent. The agent can be a monoclonal antibody, or fragment thereof, capable of binding to the C5 domain of the alphas chain of collagen VI. In some embodiments, the method can further include administering an effective amount of thiazolidinedione to said patient.

Monoclonal antibodies against endotrophin and the use thereof

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Houston, TX, United States of America

Hui Deng