Collagen Matrix, Inc.

Hui-Chen Chen

Shu-Tung Li

Debbie Yuen

An implant for the repair of bone and cartilage that includes a cell conductive zone that contains biopolymeric fibers and an osteoconductive zone that contains biopolymeric fibers and calcium-containing mineral particles. The biopolymeric fibers from one zone overlap with the fibers in the other zone forming a stable physical and mechanical integration of the two zones, thus conferring in vivo stability to the implant.

Implants for bone and cartilage repair

A carbonate apatite prepared from natural bone. The carbonate apatite has a protein content of 2000-8000 parts per million and a surface area of 15 to 70 m/g. Also provided is a method for preparing the carbonate apatite from cancellous bone particles.

Method of preparing porous carbonate apatite from natural bone

A method for preparing carbonate apatite from natural bones. The method includes obtaining cancellous bone particles; treating the bone particles with hot water and an organic solvent; repeating the treating step at least once; drying the bone particles; and heating the bone particles at 500&#xb0; C. to 620&#xb0; C. for 10 to 50 hours.

A compressed implant composite for repairing mineralized tissue. The compressed implant composite includes a matrix formed of biopolymeric fibers and a plurality of calcium- and/or silicate-based mineral particles dispersed in the matrix. The matrix constitutes 4 to 80% by weight and the mineral particles constitute 20 to 96% by weight of the composite. The composite is free of soluble collagen and is expandable to a volume 2 to 100 times of its compressed volume (e.g., upon absorption of water). Also disclosed are methods of preparing the above-described composite.

Self-expandable biopolymer-mineral composite

This invention relates to a method for preparing a porous bone implant containing a calcium-based mineral. The method includes immersing a porous matrix in an acidic solution containing a calcium-based mineral; removing the matrix from the solution; and exposing the matrix to an alkali to neutralize the acidic solution, thereby causing precipitation of the calcium-based mineral to obtain a porous bone implant containing a calcium-based mineral.

Calcium-containing bone implants

A bone implant composite comprising a collagen matrix and a calcium-based mineral, the calcium-based mineral having a particle size of 25-2000 &#x3bc;m and being interspersed in the collagen matrix; wherein the bone implant composite contains 3-60% by weight the collagen matrix and 40-97% by weight the calcium-based mineral, and has a pore size of 50-500 &#x3bc;m, a density range of 0.02-0.8 g/cm, a tensile strength range of 0.4-100 kg/cm, and a compression modulus range of 0.2-10 kg/cm. Also disclosed are methods of preparing the above-described composite.

Bone implant composite

A bone implant composite comprising a collagen matrix and a calcium-based mineral, the calcium-based mineral having a particle size of 25-2000 &#x3bc;m and being interspersed in the collagen matrix; wherein the bone implant composite contains 3-60% by weight the collagen matrix and 40-97% by weight the calcium-based mineral, and has a pore size of 50-500 &#x3bc;m, a density range of 0.02-0.8 g/cm, and a tensile strength range of 0.4-100 kg/cm. Also disclosed are methods of preparing the above-described composite.

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Wayne, NJ, United States of America

Hui-Chen Chen