Merrell Dow Pharmaceuticals

Sanofi-aventis

Merrell Pharmaceuticals, Inc.

Hugues D'Orchymont

Celine Tarnus

Luc Van Hijfte

André Zimmermann

Laurent Fraisse

Marc Bigaud

The invention relates to methods of treating or preventing malaria which comprises administering to a patient in need thereof, an effective amount of a 1H-indazole-3-carboxamide derivative of general formula (I), in the form of a base or of an addition salt with an acid, or in the form of a hydrate or of a solvate of said base or acid addition salt.

Indazolecarboxamide derivatives for the treatment and prevention of malaria

Compound corresponding to general formula (I): in which, Rrepresents a hydrogen or halogen atom, an NH, NHR, NHCOR, NO, CN, CHNHand CHNHR; or alternatively Rrepresents an optionally substituted phenyl or an optionally substituted heteroaromatic group;

Indazolecarboxamide derivatives, preparation and use thereof as CDK1, CDK2 and CDK4 inhibitors

Phosphonomethyldipeptides and process for preparation thereof

This invention relates to novel derivatives of tetralin, to the processes for their preparation, to their use as amino-peptidase inhibitors and to their end-use application as immunomodulators and as analgesic agents.

Method of using certain tetralin derivatives to produce analgesic relief

This invention relates to novel derivatives of tetralin, to the processes for their preparation, to their use as aminopeptidase inhibitors and to their end-use application as immunomodulators and as analgesic agents.

Growing community of inventors

Strasbourg, France

Hugues D'Orchymont