Centre National De La Recherche Scientifique

Institut Pasteur

Hugues Bedouelle

Philippe Despres

Frédéric Tangy

Chantal Combredet

Marie-Pascale Frenkiel

Marianne Lucas-Hourani

Erika Navarro-Sanchez

Martial Renard

Laurent Belkadi

Patrick England

Elodie Brient-Litzler

Philippe Dussart

Laetitia Bremand

The invention relates to building a chimeric polypeptide used for preventing or treating a Flaviviridae infection. The use of the inventive chimeric polypeptide for producing recombinant viral vectors such as a measles living viral vector is also disclosed.

Chimeric poly peptides and the therapeutic use thereof against a flaviviridae infection

Chimeric poly peptides and the therapeutic use thereof against a Flaviviridae infection

Method for the diagnosis or the screening of an arbovirus infection and preferably a flaviviridae infection and more preferably a flavivirus infection, reagents useful in said method and their applications. Said method comprises: (i) contacting a sample from the subject or animal with a solid support sensitized with an Ig binding protein which is directed against a specific class of Ig molecules of the subject or animal species under consideration and (ii) incubating the immunocomplex formed in (i) with a detector molecule consisting of a hybrid protein comprising at least an arboviral ED3 domain and an alkaline phosphatase (PhoA), the detection of said immunocomplex being the sign of the presence of an arbovirus in said sample.

Method for the diagnosis or the screening of an arbovirus infection, reagents useful in said method and their applications

Chimeric poly peptides and the therapeutic use thereof against a Flaviviridae  infection

The invention relates to biosensors, methods for obtaining them and their use for detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of the active site is naturally present in the form of a cystein (Cys) residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.

Biosensors, method for obtaining the same and uses thereof

The invention relates to biosensors, methods for obtaining them and their use fro detecting, assaying or locating, in direct immunofluorescence, a ligand such as an antigen or hapten, in a heterogeneous population. The biosensor includes (i) at least one fragment of a receptor which is protein in nature, capable of binding to a ligand via an active site, where at least one amino acid residues of the fragment located in the proximity of said active site is naturally present in the form of a cystein Cys residue, or is substituted with a Cys residue, and (ii) a fluorophore coupled to the Cys residue.

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Paris, France

Hugues Bedouelle