Universitéde Montreal

Mount Sinai Hospital Corporation

Hugo Lavoie

Jacques Banville

Sasmita Tripathy

Michael Dore

Joanne Tan

Pierre Louis Beaulieu

Frank Sicheri

Yannick Rose

Eric Beaulieu

Doris Schuetz

Mukund Ghavre

Marc Therrien

Thanashan Rajakulendran

Emeline Benoit

Malha Sahmi

Compounds, compositions and their use in the treatment of a proliferative disease or condition such as a said proliferative disease or disorder is associated with a RAF gene mutation and/or a RAS gene mutation. The compounds disclosed are of Formula I or a pharmaceutically acceptable salt or solvate thereof, wherein R, R, R, X, X, Xand Xare as defined herein:

Pyrido[3,2-d]pyrimidine compounds uses thereof for treating a proliferative disease

Disclosed herein are biosensors useful for detecting the dimerization of RAF and/or KSR polypeptides. These biosensors comprise fusion proteins comprising RAF and/or KSR proteins fused to bioluminescent or fluorescent proteins. Also disclosed are methods of using the biosensors to detect and measure the dimerization of RAF/RAF and RAF/KSR polypeptides by resonance energy transfer such as BRET or FRET, for example to screen for inhibitors of dimerization.

Biosensor for detecting RAF/KSR family kinase dimerization and uses thereof

Growing community of inventors

Montreal, Canada

Hugo Lavoie