G.d. Searle & Company

Hugo J Gorissen

Claude L Gillet

Alex A Cordi

Michel P Snyers

Philippe R Bovy

Georges E Lambelin

Joseph L Roba

Alexis A Cordi

William R Van Dorsser

Piedad Calderon

Philippe Janssens De Varebeke

A class of .omega.-amino-.alpha.-phenylalkanonitrile derivatives is described having use in treatment of cardiovascular dysfunctions such as hypertension. Compounds of most interest are those of the formula: ##STR1## wherein each of R.sub.1 and R.sub.2 is methoxy, R.sub.3 is hydrido, R.sub.4 is isopropyl, R.sub.5 is methyl and R.sub.6 is selected from linear alkyl, phenylpropyl, phenylbutyl and phenylpentyl.

.omega.-amino-.alpha.-phenylalkanonitrile derivatives

Deuterated 2-alkylaminoacetamide compounds are described having the alpha carbon of the alkyl side chain of the compounds substituted by one or two deuterium atoms. These compounds have pharmacokinetic properties which enable treatment of CNS diseases with lower toxic effects. These compounds are also useful in evaluating the metabolic fate of non-deuterated counterpart compounds. Of particular interest are compounds of Formula I: ##STR1## wherein X is deutero or hydrido; wherein R.sup.1 is selected from alkyl and aralkenyl; wherein each of R.sup.2 and R.sup.3 is independently selected from hydrido and alkyl; wherein each of R.sup.1, R.sup.2 and R.sup.3 having a substitutable position may be substituted with one or more halo radicals; or a pharmaceutically-acceptable salt thereof.

Alpha-deuterated 2-alkylaminoacetamide derivatives having reduced

Certain 4(5)-(biarylethyl)imidazole derivatives are selectiv3 .alpha..sub.2 -adrenergic receptor blockers and are useful as anti-depressant agents.

Biarylalkylimidazole derivatives as anti-depressants

A compound of the formula: ##STR1## wherein X.sup.1, X.sup.2, Y.sup.1 and Y.sup.2, whether or not identical are hydrogen, a halogen such as fluoro, chloro or bromo, linear or branched alkyl of 1 to 3 carbon atoms, linear or branched alkoxy of 1 to 3 carbon atoms, carboxy, alkoxy-carbonyl of 1 to 3 carbon atoms or phenyl;

.alpha..sub.2 -blocking derivatives of imidazole

Growing community of inventors

Grez Doiceau, Belgium

Hugo J Gorissen