Universidad Catolica De Cordoba

Assistance Publique-hopitaux De Paris

Université Pierre Et Marie Curie (paris 6)

Consejo Nacional De Investigaciones Cientificas Y Tecnicas (conicet)

Universidad Católica De Córdoba (ucc)

Hugo Daniel Lujan

David Klatzmann

Eliane Piaggio

The invention provides compositions for oral delivery and methods of treatment using VSP carriers, such assp. variable surface proteins (VSP), to deliver therapeutic agents. VSP drug carriers can be combined with bioactive peptides, e.g., insulin, glucagon, or hGH, and be administered orally or mucosally. VSP carriers are resistant to acidic pHs and to proteolytic degradation and protect therapeutic agents from degradation in the gastrointestinal tract.

Protozoan variant-specific surface proteins (VSP) as carriers for oral drug delivery

Modified protozoa parasites comprising simultaneous expression on its surface of at least two variable surface proteins (VSP). The modified protozoa may also simultaneously express the complete repertoire of variable surface proteins. Protozoa show reduced expression of Dicer, RNA-dependant RNA-polymerase (RdRP) enzymes or both, wherein the RdRP gene and/or the Dicer gene has been silenced. The protozoan may be any protozoan showing an antigenic variation mechanism.

Modified protozoan expressing at least two variable surface proteins (VSP), a vaccine comprising it and procedures, uses, and methods thereof

Growing community of inventors

Córdoba, Argentina

Hugo Daniel Lujan