Mycardio LLC

Beth Israel Deaconess Medical Center, Inc.

Hugi Hilmisson

Robert Joseph Thomas

The present disclosure provides systems and method of analyzing whether a sleep epoch is a REM sleep epoch or a wake epoch. In accordance with aspects of the present disclosure, a computer-implemented method includes accessing cardiopulmonary coupling data spanning a sleep period for a person, identifying an epoch in the sleep period corresponding to very-low frequency coupling in the cardiopulmonary coupling data, accessing high-frequency coupling data and/or low-frequency coupling data in the cardiopulmonary coupling data corresponding to the epoch, and designating the epoch as a REM sleep epoch or as a wake epoch based on the high-frequency coupling data and/or the low-frequency coupling data corresponding to the epoch, where the epoch is designated based on the cardiopulmonary coupling data without using non-cardiopulmonary coupling physiological data.

Systems and methods for designation of REM and WAKE states

In accordance with one aspect, a system for evaluating a health condition includes a storage containing cardiopulmonary coupling (CPC) data and heart rate data for a person for a sleep time period, one or more processors, and a memory storing instructions. When the instructions are executed by the processor(s), they cause the system to access the CPC data and the heart rate data from the storage, identify one or more time periods in the sleep time period categorized as high frequency coupling (HFC) state based on the CPC data, evaluate one or more characteristics of a portion of the heart rate data corresponding to the one or more time periods, and evaluate health condition of the person based on the one or more characteristics of the portion of the heart rate data corresponding the one or more time periods categorized as HFC state.

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Hugi Hilmisson