Abbott Laboratories Corporation

Hugh N Nellans

Leslie A Freiberg

Richard J Pariza

Carla M Edwards

Larry L Klein

Ramin Faghih

Paul A Lartey

Mark W Holladay

Alex M Nadzan

Hana A Kopecka

Kazumi Shiosaki

Youe-Kong Shue

Chun W Lin

4'-Deoxy derivatives of erythromycin having the Formula (I) ##STR1## and pharmaceutically acceptable salts thereof, which are enhancers of gastric motility but have minimal antibacterial activity, as well as pharmaceutical compositions containing the same and methods for their use and preparation.

4'-deoxyerythromycin derivatives

Process for preparing 4-deoxyerythromycin derivatives

Macrocylic lactam compounds of formula (I) ##STR1## and pharmaceutically acceptable salts thereof, wherein A is selected from ##STR2## also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.

Macrocyclic lactam prokinetic agents

Macrocylic lactam compounds of formula (i) ##STR1## and pharmaceutically acceptable salts thereof, wherein A is selected from ##STR2## also disclosed are synthetic processes and intermediates useful in the preparation of the compounds of the invention, as well as compositions containing the same and methods for their use in stimulating contractile motion of the gastrointestinal tract.

Selective and potent Type-A CCK receptor agonists of formula (I):

Derivatives of tetrapeptides as CCK agonists

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Mundelein, IL, United States of America

Hugh N Nellans