University of Texas System

Stc.unm

The Texas A&m University System

Hugh D Smyth

Matthew J Herpin

Robert O Williams, Iii

Martin J Donovan

Eric Van Oort

Ali Karimi Vajargah

Besmir B Hoxha

Silvia Ferrati

Ju Du

Justin A Smolen

Carolyn L Cannon

Parth N Shah

Ashkan K Yazdi

Marek A Osinski

Nicola Jeanne Maynard

Ibrahim M El-Sherbiny

Patricia Pereira Martins

Shayna L McGill

The claimed invention is directed to the use of a composition for use as an antimicrobial comprising an antimicrobial agent. In certain embodiments, the composition is used for treating or ameliorating inflammation in a subject and comprises an anti-inflammatory agent. The anti-inflammatory agent may include an NSAID, such as ibuprofen or diclofenac. The composition may further include solvents, anti-bacterial agents, anti-fungal agents, anti-parasitic agents, anti-viral agents, and buffers. The composition may include particles that have been processed via jet milling to reduce a diameter of the particles and to improve a flowability of the particles.

Antimicrobial and anti-inflammatory compositions

Devices, systems and methods to directly quantify molecular entities and, compounds, inactive ingredients, compositions or formulations across and into specific layers of biological membranes, such as the skin. Exemplary methods enable the determination of the amount of drug into and across tissues as well as the measurement of the effect of chemicals/compounds on membranes, mainly the skin.

Methods and apparatus for high-throughput screening for testing permeability and retention of compounds across biological barriers

Disclosed herein are compositions and methods for reducing fluid loss in a well bore, methods for wellbore strengthening and increasing the integrity of the borehole of an oil or gas well. Also disclosed are methods for artificially increasing the temperature of a subsurface formation in the wellbore to increase the apparent wellbore strength. The mechanism for accomplishing this revolves around increasing fracture propagation pressure by actively manipulating thermal wellbore stresses.

Methods for increasing wellbore strength

Disclosed herein are compositions and methods for reducing fluid loss in a well bore. Also disclosed herein are methods for wellbore strengthening and increasing the integrity of the borehole of an oil or gas well. In particular, disclosed are methods for artificially increasing the temperature of a subsurface formation in the wellbore to increase the apparent wellbore strength.

In some aspects, pegylated aminoglycoside compounds are provided. In some embodiments, m-PEG-tobramycin compounds may be used to treat a biofilm infection or reduce or treat established biofilms.

Compounds for treating biofilm infection

In some aspects, pegylated aminoglycoside compounds are provided. In some embodiments, m-PEG-tobramycin compounds may be used to treat a biofilm infection or reduce or treat established biofilms. The present invention provides, in various aspects, compounds and methods for the treatment of infections, such as biofilm infections or chronic biofilm infections. The chronic biofilm infection may occur in wounds, implanted devices, immunocompromised patients, people with cystic fibrosis, eye infections, etc.

The invention relates to solid compositions that may be suitable for administering a therapeutic agent to a subject. The invention also relates to methods of making such solid compositions. The invention further relates to methods of treating a disease, condition, or disorder by administering to a subject such solid compositions.

Solid compositions for pharmaceutical use

Active multifunctional nanoparticles provide significant enhancement of the efficacy of model therapeutic and gene agents due to increased diffusion and penetration through mucus and biological barriers under the influence of a magnetic field.

Active nanoparticles and method of using

There is provided methods for administering a toroidal pharmaceutical composition to a subject. The method includes dispensing a toroidal pharmaceutical composition, and allowing the toroidal pharmaceutical composition to contact a target organ of the subject, thereby administering the toroidal pharmaceutical composition. There are additionally provided toroidal aerosol delivery systems.

Toroidal pharmaceutical formulations

A dry powder delivery device may be configured to provide micronized dry powder particles to airways of a user. The device may include a cylindrical container delimiting a chamber containing at least one magnetically-responsive object, a motor external to said chamber, a magnet external to the chamber and rotatably coupled with the motor, and an outflow member configured to direct airflow to a user. The magnetically-responsive object may be coated with micronized dry powder particles, and the motor may be operable to rotate the magnet about an axis. Rotation of the magnet creates a magnetic field that causes the magnetically-responsive object to move in response to the magnetic field and collide with a side wall of the container to deaggregate the dry powder particles and aerosolize the dry powder in the chamber.

Dry powder nebulizer

Swellable particles for delivery of a drug or other working agent to the pulmonary system are provided. The swellable particles include a dehydrated (dry) aerodynamic particle diameter of 5 &#x3bc;m or less to enable delivery to the respiratory tract, such as for example to the tracheo-bronchial airways of the upper respiratory tract and/or to the alveolic regions of the deep lung, and a hydrated particle diameter that is greater than 6 &#x3bc;m volume mean diameter to retard or prevent their phagocytosis by the macrophages present in airways of the respiratory tract.

Growing community of inventors

Westlake, TX, United States of America

Hugh D Smyth