Fisons Ltd.

Hugh Cairns

Joachim Augstein

John King

Thomas B Lee

Dennis Hunter

Anthony R Payne

Roger C Brown

David Cox

Albert Chambers

Norman Harold Rogers

Anthony Howard Ingall

John L Suschitzky

Kenneth Brown

Richard Hazard

Peter M Greenhalgh

Brian Howlett

Roger E Altouyan

Nigel Chadwick

There are described compounds of formula I ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.CE--O--, and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, hydroxy, alkyl, halogen, alkenyl, alkoxy, or --NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2, which are the same or different, are each hydrogen or alkyl,

7,6 Dioxo-4H,6H-pyrano[3,2-g]quinoline dicarboxylic acids and

There are described compounds of formula I, ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --CZC(G.sub.1).dbd.(G.sub.2)--Z--,

Pyranoquinolinones and analogs thereof

There are described salts of 1,3-bis(2-carboxychromon-5-yloxy)propan-2-ol with certain long acting or .beta.2 selective bronchodilators. There are also described certain pharmaceutical mixtures comprising

Pharmaceutical compositions containing sodium chromoglycate and .beta.2

There is described the compound of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof. Processes for making the compound and pharmaceutical, e.g. anti-asthmatic, compositions containing it are also described.

5-(2-Hydroxypropoxy)-8-propyl-4H-1-benzopyran-4-one-2-carboxylic acid

There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, or an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain

N-Substituted-quinolin-4-one-2-carboxic acid derivatives

There is described a salt of 2,8-dicarboxy-4,6-dioxo-10-propyl-4H,6H-benzo(1,2-b:5,4-b')dipyran with a pharmaceutically acceptable organic cation, the salt having a solubility of less than 31 w/w in water a 20.5.degree. C. There are also described processes for making the salts and pharmaceutical, e.g. anti-allergic, compositions containing them.

Compounds

There is described a salt of 2,8-dicarboxy-4,6-dioxo-10-propyl-4H,6H-benzo(1,2-b:5,4-b')dipyran with a pharmaceutically acceptable inorganic cation, the salt having a solubility of less than 3% w/w in water a 20.5.degree. C. There are also described processes for making the salts and pharmaceutical, e.g. anti-allergic, compositions containing them.

Inorganic salts of

There are described compounds of formula I, ##STR1## in which an adjacent pair of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.CE--O--, and the remainder of R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, each represent hydrogen, hydroxy, alkyl, halogen, alkenyl, alkoxy, or --NR.sub.1 R.sub.2 in which R.sub.1 and R.sub.2, which are the same or different, are each hydrogen or alkyl, and

Thiopyrano-benzopyrans, compositions and method of use thereof

There are described compounds of formula I, ##STR1## in which E is a --COOH, a 5-tetrazolyl or an (N-tetrazol-5-yl) carboxamido group,

There are described compounds of formula I, ##STR1## in which R.sub.5 to R.sub.8 may be a variety of substituents, OR AN ADJACENT PAIR OF R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a chain --COCH.dbd.C(COOH)NRh--, Or one of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 form a group of formula II, ##STR2## in which Ra, Rb and Rc have the same significances as R.sub.5, R.sub.6, R.sub.7 and R.sub.8, X is an optionally interrupted or substituted hydrocarbon chain, Rg and Rh, which may be the same or different are each alkyl, alkenyl, phenyl-alkyl, alkanoyl, benzoyl or phenylalkanoyl, Or Rg and R.sub.8 and/or Rh and Rc in formula II, together form a chain --(CH.sub.2).sub.n --, and n is 2, 3 or 4. There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing the compounds.

4-Oxo-2-carboxyl quinoline derivatives used as antiallergic compounds

There are described compounds of formula Ix, ##STR1## IN WHICH ONE OR MORE ADJACENT PAIRS OF P, Q, R and T represent a chain of formula XX, ##STR2## or a group of formula X, ##STR3## in which Ba and Bb represent the pair of groups:- a carbon-carbon bond and --CRa.dbd.CRb--; or an adjacent pair of P, Q, R and T represent a group of formula XI, ##STR4## Ra and Rb and those of P, Q, R and T which do not form a chain of formula XX or a group of formula X or XI may be the same or different and each represents hydrogen; alkyl; alkoxy; alkenyl; alkenyloxy; alkyl or alkoxy, substituted by a hydroxy, alkoxy, aryl or halo group; amino; mono- or di-lower alkylamino; aminoalkoxy; aminoalkoxy substituted by a lower alkyl group; nitro; hydroxy; halogen; acyl; or aryloxy. There are also described processes for making the compounds and pharmaceutical, e.g. anti-allergic, compositions containing them.

Carboxamido tetrazoles

There are described compounds of formula I, ##STR1## in which R.sub.5, R.sub.6, R.sub.7 and R.sub.8, which may be the same or different, are hydrogen, alkyl C2 to 6, alkoxy C2 to 8, hydroxy-alkoxy C3 to 8, and R.sub.5 may be hydroxy, provided that one or two of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 are other than hydrogen, and pharmaceutically acceptable derivatives thereof. The compounds of formula I are indicated for use in the treatment of asthma, and pharmaceutical compositions containing them and processes for their preparation are also described.

Benzopyranyltetrazoles as antiasthma agents

There are described certain mono-chromone-2-carboxylic acids of formula, ##STR1## having one substituent in the 5 or 6 position or having 2 or more substituents in the 5,6,7 or 8 positions. There are also described processes for making the compounds and pharmaceutical compositions, for the treatment of asthma, containing the compounds.

6,8-Di-t-butyl-4-oxo-4H-1-benzopyran-2-carboxylic acid and derivative

There are described compounds of formula I, ##STR1## and pharmaceutically acceptable derivatives thereof, in which R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are the same or are different and each is a hydrogen or halogen atom or an alkyl, hydroxy, alkoxy, or substituted alkyl or alkoxy group, (for example a hydroxy-alkoxy, alkoxyalkoxy or carboxyalkoxy group), and X is a saturated or unsaturated, substituted or unsubstituted, straight or branched hydrocarbon chain which may be interrupted by a carbocyclic or heterocyclic ring, or by one or more oxygen atoms or carbonyl groups. There are also described processes for making the compounds and pharmaceutical compositions, for the treatment of asthma, containing the compounds.

The treatment of asthma, hay fever or urticaria

There are described certain mono-chromone-2-carboxylic acids of formula, ##SPC1## Having one substituent in the 5 or 6 position or having 2 or more substituents in the 5,6,7 or 8 positions. There are also described processes for making the compounds and pharmacetuical compositions, for the treatment of asthma, containing the compounds.

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Loughborough, United Kingdom

Hugh Cairns