Lexicon Pharmaceuticals, Inc.

Hugh Alfred Burgoon, Jr

Wenxue Wu

Ramanaiah C Kanamarlapudi

Haiming Zhang

Zhi-Cai Shi

Iain Fraser Pickersgill

Matthew Mangzhu Zhao

Mark S Bednarz

Jie Yan

Shinya Iimura

Qiuling Song

Ross Mabon

David Brent Rawlins

Bryce Alden Harrison

Nicole Cathleen Goodwin

Christopher Frampton

Brett A Marinelli

Suzanne Buttar

Jason Patrick Healy

Ying Jade Liu

Dennis Stewart Rice

Norris Andrew Whitlock

Ying Liu

Christopher Stephen Frampton

Suzanne Marie Buttar

Methods useful for preparing compounds of formula I: and salts thereof are disclosed. Also disclosed are intermediates useful in the preparation of such compounds.

Methods of preparing 4-phenyl-6-(2,2,2-trifluoro-1-phenylethoxy)pyrimidine-based compounds

Intermediates and synthetic processes for the preparation of substituted phenylalanine-based compounds (e.g., of Formula I) are disclosed: 

Compounds useful in the preparation of tryptophan hydroxylase inhibitors

Inhibitors of LIM kinase 2 are disclosed, along with pharmaceutical compositions comprising them and methods of their use. Particular compounds are of the formula: 

LIMK2 inhibitors, compositions comprising them, and methods of their use

Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol and hydrates thereof are disclosed, as well as compositions comprising them and methods of their use.

Solid forms of (1R,2S,3R)-1-(2-(isoxazol-3-yl)-1H-imidazol-4-yl)butane-1,2,3,4-tetraol and methods of their use

1-phenyl-1H-pyrazole-based compounds

Novel methods of synthesizing piperazines, piperidines and related compounds are disclosed, as are compounds useful for their preparation.

Synthesis of piperazines, piperidines and related compounds

Process for the preparation of substituted phenylalanines

Growing community of inventors

Hamilton, NJ, United States of America

Hugh Alfred Burgoon, Jr