Intervet Inc.

Intervert Inc.

Intervet International B.v.

Huchappa Gowda Jayappa

Kevin O'Connell

Terri L Wasmoen

Terri Lee Wasmoen

Maarten Hendrik Witvliet

Theodorus Jansen

Nallakannu P Lakshmanan

Rhonda LaFleur

Catherine M Peters

Randall Gene Davis

Muralidhar S Deshpande

Kevin O'connell

Rhonda Lafleur

Kevin A O'connell

The present invention describes a process for the preparation of an antigen composition, which antigen composition can be used to prepare a ready-to-use vaccine for swine, for preventing or reducing infection byor PCV2 and associated signs of disease. The process is characterised in that it comprises a step of admixing a PCV2 antigen to a pre-formed antigen/adjuvant complex of anantigen adsorbed to an Aluminium-hydroxide adjuvant. This way a PCV2/combination vaccine can be prepared that is highly effective already after a single administration, against infection and disease byand PCV2 either when in single or in combined infections. Also the vaccine has very good safety upon administration, is ready-to-use, and is economically feasible.

Process for ready-to-use PCV/M.Hyo combination vaccine

The present invention describes vaccines that compriseType alpha toxoids, antigenic fragments thereof, inactivated antigenic fragments ofType alpha toxins, or any combination thereof. The present invention further describes methods of using with these vaccines to protect animals against clostridial diseases. The present invention also describes methods of making these vaccines.

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The present invention pertains to vaccines suitable for administering systemically that comprise live aro mutant bacteria, an adjuvant, an aromatic supplement, or both an adjuvant and an aromatic supplement. The present invention also pertains to the manufacture of such a vaccine and a method of protecting an animal by administration of the vaccine.

Vaccines with live bacterial isolates for systemic administration

The present invention discloses methods for protecting newborn calves against neonatal diarrhea by vaccinating pregnant cows and/or pregnant heifers, while minimizing the number of separate occasions producers are required to assemble the cattle.

Methods of immunizing pregnant heifers at three months of gestation

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