Firmenich Sa

Hubert Mimoun

Wolfgang K Giersch

Pierre-Alain Blanc

Jean-Marc Gaudin

Kamaluddin Abdur-Rashid

Robert Harold Morris

Valentin Rautenstrauch

Raphaël Churlaud

Eric Brazi

René Challand

Francois Delay

Jean-Paul Leresche

Serge Bonnaudet

G&uuml;nter Holzner

Philippe Schneider

Jo&euml;l Pastori

Alexander Zaslona

Chengguo Jia

The present invention relates to a preparation of &#x3b2;-&#x3b3; ene carboxylic or ketone derivatives, which may also have particular requirement on the configuration of the carbon-carbon double bond. The method requires a thermal treatment of &#x3b1;-&#x3b2; unsaturated malonate or acetylacetonate derivatives in the presents of at least one carboxylic acid and at least one alkaline, alkaline-earth or lanthanide halide or carboxylates.

Process for the preparation of &#x3b2;-&#x3b3; ene carbonyl derivatives

Catalysts of formula[Ru(L)(L')XY]&#x2003;&#x2003;(II)wherein X and Y represent simultaneously or independently a hydrogen or halogen atom, a hydroxy group, or an alkoxy, carboxyl or other anionic radical, m is 1 or 2, w is 1 when m is 1 and w is 0 when m is 2, L is a phosphino-amine or phosphino-imine bidentate ligand and L&#x2032; a diphosphine, are useful for the hydrogenation of substrates having a carbon-hetero atom double bond.

Catalytic hydrogenation processes

The present invention relates to a process for the oxidation, in an inert solvent, of a non-aromatic or non-enonic ethylenic bond or of a non-conjugated cyclic ketones into the corresponding epoxides, respectively lactone, using HOas oxidant, a content in water of the reaction medium below 15% w/w and, as sole catalyst, an alkaline or alkaline earth salt or complex.

Process for the preparation of lactones or epoxides

The catalysts of formula (II): [Ru(L)(L')XY], wherein X and Y represent simultaneously or independently a hydrogen or halogen atom, a hydroxy group, or an alkoxy, carboxyl or other anionic radical, m is 1 or 2, w is 1 when m is 1 and w is 0 when m is 2, L is a phosphino-amine or phosphino-imine bidentate ligand and L&#x2032; a diphosphine, are useful for the hydrogenation of substrates having a carbon-hetero atom double bond.

The invention concerns a fatty alcohol obtainable by a method which consists in reducing the carbonyl function of a vegetable or animal oil, the method consisting in reacting said vegetable or animal oil with appropriate amounts of polymethylhydroxysiloxane (PMHS) in the presence of a catalytic system prepared from a metal salt or complex and a reduction agent, followed by hydrolysis of the resulting siloxane with a basic agent and separating and purifying the desired alcohol thus formed. Said alcohol can be used in a perfume composition, in particular as solubilizing agent.

Use of fatty alcohol in a perfume composition

A reductive system including a silane, preferably PMHS, and an active zinc compound, which is monomeric and not a hydride, wherein a reduction of a carbonyl substrate to a corresponding alcohol is achievable.

Reduction of carbonyl compounds by a silane in the presence of a zinc catalyst

A process for the enantioselective reduction of prochiral ketones to chiral alcohols by (a) the reaction of a prochiral ketone with a silane agent, which is present in a stoichiometric quantity, in the presence of a catalyst derived from a Zn, Co or Cd precursor compound and from a chiral amine, imine, alcohol or amino alcohol ligand; (b) the hydrolysis of the siloxane obtained using an appropriate agent; and (c) the separation and purification of the optically active alcohol formed. Polymethylhydrosiloxane (PMHS) is a preferred silane agent, zinc is a preferred metal, and the precursor compound is produced by reacting a salt or complex of the respective metal with the reducing agent. In another embodiment, an appropriate salt of the chosen metal is used directly in the reaction with the chiral ligand to produce the catalytic form after reaction with the ligand. The process enables high enantiomeric excesses (ee) to be obtained in chiral alcohols.

Enantioselective reduction of ketones with a silane agent/metal compound/ chiral ligand system

Porous polymethylsilsesquioxane with adsorbent properties

Enantioselective reduction of ketones with a silane agent/metal compound/chiral ligand system

The present invention relates to a process for the preparation of alcohols by reduction of the carbonyl function in substrates belonging to the class of aldehydes, ketones, esters or lactones, which substrates may contain unsaturated functions other than carbonyl. This process includes the steps of reacting the carbonyl substrate with stoichiometric amounts of a silane in the presence of catalytic amounts of an active zinc compound which is monomeric and not a hydride, hydrolyzing the thus-obtained siloxane with a basic agent, and separating and purifying, if necessary, the thus-obtained alcohol. The catalytically active compound is generally obtained by the reaction of an oligomeric or polymeric precursor compound of zinc with a complexing agent.

The compounds according to the general formula

Unsaturated ketones and their use in perfumery

Aldehydes, ketones, esters and lactones may be reduced using a reductant system consisting of a silane derivative and a metal hydride to give good yields of the corresponding alcohols. The reductant system used in the method enables preferential reduction of the carbonyl function. In one embodiment, the reductant system consists of polymethylhydroxysilane and a metal hydride, the hydride being prepared in situ or ex situ from a metal salt or complex by means of a reaction with a reducing agent.

Process for the preparation of alcohols

Perfuming ingredients which include at least one macrolide of formula ##STR1## having a double bond in one of the positions indicated by the dotted lines and wherein the symbol R represents a hydrogen atom or a methyl radical, are described. They are useful for the preparation of perfumes and perfumed consumer products to which they impart musky odors with original nuances.

Growing community of inventors

Challex, France

Hubert Mimoun