Symrise Ag

Basf Se Corporation

Haarmann & Reimer Gmbh

Symrise Gmbh & Co Kg

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Arnold Machinek

Horst Surburg

Michael Backes

Heiko Oertling

Günter Kindel

Ulrike Simchen

Wolfgang Siegel

Thomas Subkowski

Claus Bollschweiler

Jens Wittenberg

Sven Siegel

Benoit Join

Torsten Kulke

Rita Lages

Ralf Pelzer

Gerhard Krammer

Erich Dilk

Ingo Wöhrle

Axel Schöning

Frank Aickele

Rahim Brodhage

Jekaterina Ongouta

Gabriele Neuendorff

Martin Weisel

Benoît Join

Bernd Wiedwald

Klaus Sorge

Constanze Brocke

Susanne Mundt

Tom Somers

The invention relates primarily to a method of modulation, preferably of in vitro and/or in vivo modulation, of the cold menthol receptor TRPM8, wherein the receptor is contacted with at least one modulator selected from the group consisting of the compounds of the structure type 1 described herein. The present invention further relates to corresponding uses and compositions comprising such compounds.

Use of physiological cooling active ingredients, and compositions comprising such active ingredients

Proposed are preparations, comprising special amides and menthol or menthol compounds or aromatic substances, characterized in that they have improved flavor and scent properties, and also that they allow the production of preparations, particularly emulsions with improved shelf life.

Preparations having a cooling effect

The invention relates to a TRPM8 modulator for achieving a cooling effect on the skin or a mucous membrane.

Use of physiological cooling active ingredients, and agents containing such active ingredients

Preparations

Cooling preparations

A mixtures which contain (a) at least one phenylalkenal of formula (I) wherein Rand Rindependently represent hydrogen, a methyl or phenyl group, Rrepresents hydrogen, a phenyl group, alkenyl group or a linear or branched alkyl group with 1 to 5 carbon atoms, and the broken double lines independently represent a single bond or a double bond, and (b) at least one physiological cooling agent.

Mixtures having improved cooling effect

The present invention primarily concerns teeth cleaning compounds containing menthol for use with a toothbrush, preferably tooth pastes, tooth cr&#xe8;mes, tooth cleaning gels or tooth powders. Such a tooth cleaning compound according to the invention contains menthol and a quantity, for masking the bitterness of the menthol, of menthane carboxylic acid-N-(4-methoxyphenyl)-amide (WS-12) of the following formula (Ia), in particular of the following formula (Ib), i.e. L-menthane carboxylic acid-N-(4-methoxyphenyl)-amide.  The present invention also concerns the use of menthane carboxylic acid-N-(4-methoxyphenyl)-amide (WS-12) of the formulas (Ia) or (preferably) (Ib) to mask the bitter taste of menthol in a teeth cleaning compound. The present invention also concerns a method for dissolving menthane carboxylic acid-N-(4-methoxyphenyl)-amide (WS-12) in a teeth cleaning compound and a method for masking the bitterness of menthol in a teeth cleaning compound.

Products comprising a flavoring agent composition

The present invention relates to the use of 4-methyl-delta-hexylactone for imparting, modifying and/or intensifying one or more smell or flavor impressions from the group consisting of hay, coumarin, lactone and richness in the mouth.

Uses of 4-methyl-5-hydroxy-hexanoic acid lactone

A preparation for creating a clearing feeling in a pharyngeal cavity and nasal cavity comprising a rhinologically active substance of formula (I):  In formula (I), variable x and substituents R, Rand Rhave the following meanings:

Utilization of rhinologically active substances

The present invention relates to d,l-menthol and optionally additionally l-menthol-containing mixtures, which are liquid at normal pressure and a temperature of 20&#xb0; C. or higher. The present invention further relates to products that comprise such a mixture or that are preparable by mixing or contacting such a mixture with further ingredients, and novel processes for preparing menthol-containing products.

Mixture containing menthol

The present invention relates to alkyl-substituted tetrahydropyrans, mixtures containing these alkyl-substituted tetrahydropyrans, their respective use and corresponding flavored products.

Alkyl-substituted tetrahydropyrans as flavoring substances

The invention relates to a mixture of compounds having the sensory properties of wintergreen, to fragrance and flavoring compositions containing said mixture and to flavored and perfumed products containing said mixture, to a method of adding a wintergreen flavor, odor or note to (non-wintergreen) flavored or perfumed products. Further the present invention relates to the use of said mixture as an enhancement, or as complete or partial replacement for methyl salicylate, in particular in chewing gum, foods, dentrifices, mouthwashes and other orally consumable products. The mixture comprises or consists of dihydroanethole, o-anisaldehyde, 1,3-dimethoxybenzene, 2'-hydroxyacetophenone, and optionally 2-methoxyacetophenone.

Mixture with wintergreen odor and flavor

Acyclic compounds containing an ether functionality external to the ring can be used as rhinologically active substances. In the regions of the mouth, the throat and the airways they produce a refreshing and clearing feeling.

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Höxter, Germany

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