Rhone-poulenc Chimie

Rhodia Chimie

Hubert Kempf

Laurent Saint-Jalmes

Jean-Roger Desmurs

Jean-Michel Grosselin

Gilbert Guidot

Jean-Pierre Lecouve

Serge Ratton

Vincent Schanen

Dominique Stephan

Francis Back-Posta

The invention concerns a method for using a carbamoyl fluoride as fluorinating agent. Said method consists in treating a derivative bearing a halogen-containing carbon, with a carbamoyl fluoride at a temperature not less than 70 &deg; C. and in maintaining the ratio between the sum of hydrofluoric acid (HF) and carbamoyl fluoride as well as between the sum of exchangeable halogen atoms, isocyanate functions and carbamoyl fluoride &lsqb;(HF&plus;carbamoyl fluoride)/(exchangeable halogen&plus;isocyanate&plus;carbamoyl fluoride)&rsqb; at a value not more than 1.2; then in carrying out a catalysis process with tin, antimony and/or titanium salt. The invention is applicable to synthesis of fluorinated derivatives.

Method for using a carbamoyl fluoride as fluorinating agent

The invention concerns a method for the synthesis of chlorinated aniline on the ring and comprising at least a sp3 hybridization carbon atom both perhalogenated and bearing a fluorine atom. Said method is characterized in that it comprises a step which consists in chlorinating a precursor aniline of said chlorinated aniline, said chlorination being carried out in a hydrofluoric medium capable of exchanging chlorine and fluorine in benzyl position. The invention is useful for the synthesis of organofluorinated and/or chlorinated compounds.

Chlorination of an aniline in a hydrofluoric medium

A process and reagent for allylating a nucleophile preferably of formula (V).

Allylation reagent and process for allylating a nucleophile

N-phenylbenzoquinone-imine is prepared by oxidizing N-(4-hydroxyphenyl)aniline in a liquid, at least partially organic reaction medium, in the presence of a basic compound and, advantageously, a catalytically effective amount of at least one manganese, copper, cobalt and/or nickel compound; this imine can be reacted with an aliphatic or cycloaliphatic amine to produce an N-phenyl-N'-cycloalkyl-para-phenylene-diamine and an N-phenyl-N'-cycloalkyl-2,5-cyclohexadiene-1,4-diimine, such 1,4-diimine itself being easily reduced to the corresponding p-phenylenediamine.

Preparation of n-phenylbenzoquinone-imine and converting same into

A process for the preparation of N-monoalkyl or N-monoalkenyl anilines wherein the aniline is contacted with an alkyl or alkenyl halide in the presence of a non-quaternizable organic base and a salt of a non-quaternizable organic base.

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Mulhouse, France

Hubert Kempf