Biomerieux, Inc.

Université Des Sciences Et Technologies De Lille

University Des Sciences Et Technologies De Lille

Biomerieux Sa

Université Des Sciences Et Technologies De Lille Saic

Hubert Hondermarck

Genevieve Choquet-Kastylevsky

Geneviève Choquet-Kastylevsky

Ikram El-Yazidi Belkoura

Eric Adriaenssens

Yohan Demont

Geneviéve Choquet-Kastylevsky

Yohann Demont

Laurent Dolle

A ProNGF inhibitor for preparing a drug, said drug being in particular useful for blocking remote dissemination and cell invasion in patients suffering from cancer, in particular breast, thyroid or lung cancer.

Method for ProNGF assay for in vitro diagnosis of cancer in particular breast, thyroid or lung cancer and therapeutic use of ProNGF

The present invention concerns a method for in vitro diagnosis of cancer, in particular breast, thyroid or lung cancer, which consists in determining the presence of ProNGF in a biological sample derived from a patient suspected of suffering from cancer, in particular breast, thyroid or lung cancer. Said method may be used for early diagnosis, screening, therapeutic follow-up, prognosis and for diagnosing relapses in cancer and in particular breast, thyroid or lung cancer. The present invention also concerns the use of a ProNGF inhibitor for preparing a drug, said drug being in particular useful for blocking remote dissemination and cell invasion in patients suffering from cancer, in particular breast, thyroid or lung cancer. The invention is applicable in the field of diagnosis and therapeutics.

The present invention concerns a method for the in vitro diagnosis of breast cancer which consists in determining the presence of NGF in a biological sample derived from a patient suspected of suffering from breast cancer. Said method may be used both in early diagnosis, screening, therapeutic follow-up and prognosis, and in the diagnosis of relapse in the case of breast cancer. The present invention also concerns the use of an NGF binding partner or of an NGF inhibitor for preparing a medicinal product, said medicinal product being in particular useful for blocking tumor proliferation and remote dissemination in patients suffering from breast cancer.

Method for NGF assay for in vitro diagnosis of breast cancer and therapeutic use

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Villeneuve d'Ascq, France

Hubert Hondermarck