Boehringer Ingelheim International Gmbh

Boehringer Ingelheim Pharma Gmbh & Co Kg

Boehringer Ingelheim Pharma Kg

Other

Boehringer Ingelheim Pharma Gbmh Co. Kg

Hubert Hoelz

Herbert Wachtel

Dieter Hochrainer

Christoph Kreher

Christian Scheffler

Burkhard Metzger

Georg Boeck

Alfred Von Schuckmann

Joachim Eicher

Martin Meisenheimer

Torsten Kuehn

Rolf Kuhn

Stefan Lustenberger

Jochen Ziegler

Richard Thomas Lostritto

Juergen Nagel

Johannes Geser

Gilbert Wuttke

Andree Jung

Marc Rohrschneider

Frank Herrmann

Christel Schmelzer

Josef Gatz

Friedrich Schmidt

Hans-Hermann Weil

Markus Mueller

Robert Gerhard Winkler

Joern-Eric Schulz

Julio C&eacute;sar Vega

Mariola Mann

Julio César Vega

Daniela Bothe

Bettina Berner

A nebulizer and a container with a fluid for such a nebulizer are proposed. The container comprises an indicator device fixedly mounted on the bottom of the container. When a predetermined number of uses of the container () with the nebulizer () has been reached or exceeded, a signal element becomes visible on the indicator device. The indicator device stops further use of the container in a locked state when a predetermined number of uses has been reached or exceeded. Then, the nebulizer is partially opened and blocked against further use. After replacement of the container including the indicator device, the nebulizer can be used again.

Nebulizer and container

A nebulizer and a container with a fluid for such a nebulizer are described, the container comprising an indicator device fixedly mounted on the bottom of the container, the indicator device stopping further use of the container in a locked state when a predetermined number of uses has been reached or exceeded, and when the nebulizer is partially opened, it is blocked against further use, and after replacement of the container including the indicator device, the nebulizer can be used again.

Nebulizer

The invention relates to pharmaceutical active substances, active substance mixtures and formulations for use as an aerosol in propellant-containing [1.1.1.2-tetrafluoroethane (HFC-134a) or 1.1.1.2.3.3.3-heptafluoropropane(HFC-227)] metered-dose aerosols and the metered-dose aerosols for administering these active substances, active substance mixtures and formulations.

Dosage aerosols for the application of pharmaceutical formulations

The invention relates to a powder inhaler with at least one specially sharpened needle, to ensure the precise piercing or cutting open of capsules and hence the optimum delivery of powdered medicament compositions, medicament formulations or medicament mixtures, as well as ensuring that little effort is needed to perforate or cut open the capsule.

Needle for piercing a powder capsule for inhalation

The present invention relates to medicament blisters for powder inhalers. The blisters according to the invention contain an inhalable powder comprising a medicament. The blisters are characterized by a reduced permeability for water vapor, which is achieved by decreasing the height of the sealing lacquer layer.

Medicament blister

The present invention relates to capsules for housing pharmaceutical preparations for powder inhalers with increased medicinal product safety and capsules for pharmaceutical preparations for powder inhalers with improved adaption to use in powder inhalers. The capsules consist of non-water-soluble, hydrophobic plastics, which themselves do not substantially influence the pharmaceutical quality of the contents, but improve the usability of the filled capsules in respect of their operation, the period of use and/or the geographical location of their use and are advantageous in various steps from manufacture to use.

Two-part capsule with pre-closure for housing pharmaceutical preparations for powder inhalers

The invention relates to pressurized gas formulations for dosage aerosols, in which a medicament is formulated suspended in TG 227 ea (1,1,1,2,3,3,3-heptafluoropropane) and/or TG 134 a (1,1,1,2-tetrafluoroethane) as a propellant, and to their use for producing a medicament. The aerosol is preferably an inhalation aerosol.

Aerosol suspension formulations with TG 227 ea or TG 134 a as propellant

The invention relates to a hand-held device (), as depicted in exemplary FIG., for metered dispensing of sprayable substances, particularly medicaments for inhalation, with a cartridge () that can be moved into the dispensing position, by pressure being applied to a housing, and with a step-by-step indexing mechanism () which is entrained by the cartridge () in the opening travel thereof and which is used to record and display the dispensing actuations that have been performed. In order to suitably design a hand-held device of the type in question with a simplified structure, in such a way that the indexing steps can be performed smoothly and safely without connection to the cartridge, it is proposed that slits () extend obliquely only over part of the travel of the step-by-step indexing mechanism housing () and that the guide pins () guided therein move, over the remainder of the travel of the step-by-step indexing mechanism (), parallel to the longitudinal axis (x-x) of the step-by-step indexing mechanism.

Inhaler device

In a method for checking the permeability rate of a closed container () with respect to a medium, in particular for checking the permeability rate of a film-type container for accommodating a film container for accommodating a pharmaceutical active constituent formulation, the container () is filled with a medium, charged with a gas, and the increase in the amount of medium in the gas is then analysed.

Method for checking the permeability rate of a closed container

The measurement of the particle size distribution of an aerosol is of crucial importance in pharmaceutical development. A prerequisite for this is a valid method, e.g. the cascade impactor method described in the pharmacopoeias. It requires measurement of the active substance concentration in order to determine the particle size distribution. The invention provides a process which makes it possible to measure the size of aerosol droplets containing pharmaceutical substances which are unstable in the event of changes in the pH.

Process for determining the particle size distribution of an aerosol and apparatus for carrying out such a process

Disclosed herein are methods for measuring the particle size distribution of a pharmaceutical aerosol, including methods utilizing laser diffraction.

Measuring particle size distribution in pharmaceutical aerosols

The present invention relates to corrosion resistant stainless steel canisters for propellant-containing aerosol formulations for use in propellant gas-operated inhalers.

Stainless steel canister for propellant-driven metering aerosols

The present invention relates to corrosion resistant stainless steel canisters for propellant-containing aerosol forumlations for use in propellant gas-operated inhalers.

Growing community of inventors

Oberheimbach, Germany

Hubert Hoelz