Warner-lambert Company

Goedecke Aktiengesellschaft

Goedecke Gmbh

Godecke Aktiengesellschaft

Hubert G Barth

Johannes Hartenstein

Gerhard Satzinger

Edgar Fritschi

Christoph Schachtele

Claus Rudolph

Klaus Steiner

Simon Schneider

Manfred F Herrmann

Hartmut Osswald

Ulrich Bayer

Manfred Westermayer

Ulrike Wolfsperger

Jurgen Kleinschroth

Volker Ganser

Reinhard Reck

Julian Aranda

Hans-Jurgen Betche

Hans-J&uuml;rgen Betche

Hans Jurgen Betche

Ilse-Dore Schutt

Ila Sircar

Gunter Weinheimer

Uwe Trostmann

Gunter Wolf

Horst-Dietmar Tauschel

Gerd Bartoszyk

Walter Kolch

Hans-Jürgen Betche

The invention concerns a process for the preparation of N-aryl-aza-heterocycles of the general formula Iby reaction of aza-heterocycles with activated aryl halides with use of caesium carbonate without addition of further catalysts at room temperature.

Process for the arylation of aza-heterocycles with activated aromatics in presence of caesium carbonate

Method for arylating aza-heterocycles with activated aromatic compounds in the presence of caesium carbonate

Method for producing symmetrical and asymmetrical carbonates

METHOD FOR THE SIMPLIFIED PRODUCTION OF (3-CHLORO-4-FLUOROPHENYL)-&lsqb;7-(3-MORPHOLIN-4-YL-PROPOXY)-6-NITRO-QUINAZOLINE-4-YL&rsqb;-AMINE OR (3-CHLORO-4-FLUOROPHENYL)-&lsqb;7-(3-MORPHOLIN-4-YL-PROPOXY)-6-AMINO-QUINAZOLINE-4-YL&rsqb;-AMINE

The invention relates to a method of producing heterocyclic carbamates of the general formula (I) by reacting aza-heterocyclic compounds with alkyl- or aryl-halides in the presence of carbon dioxide and alkali carbonate, and to new compounds of the general formula (I).

Method of producing heterocylic carbamates from aza-heterocyclic compounds and carbon dioxide

The present invention is concerned with the use of indolocarbazole imides of the general formula (I): ##STR1## for the preparation of pharmaceutical compositions for the treatment and/or prevention of cancer, virus diseases (for example HIV infections), heart and blood vessel diseases (for example high blood pressure, thromboses, heart rhythm disturbances and atheroscleroses), bronchopulmonary diseases, degenerative diseases of the central nervous system (for example Alzheimer's disease), inflammatoryl diseases (for example rheumatism and arthritis), diseases of the immune system (for example allergies), as well as psoriasis and for use as immune suppressives; as well as new compounds of general formula (I).

Indolocarbazole imides and the use thereof

Bis-indolyl maleinimide or indolopyrrolo carbazole containing an amino

The present invention provides bis-(1H-indol-3-yl)maleinimide derivatives and the pharmacologically acceptable salts thereof, processes for the preparation of these compounds, and pharmaceutical compositions containing them for the treatment of heart and blood vessel diseases, such as thromboses, arteriosclerosis, hypertension, of inflammatory processes, allergies, cancer, and certain degenerative damages of the central nervous system, as well as of diseases of the immune system and viral diseases.

Bis-(1H-indol-3-yl)-maleinimide derivatives, processes for the

New indolocarbazoles of formula: ##STR1## or a pharmaceutically acceptable salt thereof, processes for their preparation, compositions containing, and methods for using the composition for the inhibition of protein kinases, such as protein kinase C, for the prevention and/or treatment of heart and blood vessel diseases such as thromboses, arterioscleroses, hypertension, or for inflammatory processes, allergies, cancers, viral diseases, and certain degenerative damages of the central nervous system are disclosed.

Indolocarbazole derivatives, processes for their preparation and

Bis-(1H-indol-3-YL)-maleinimide derivatives, processes for the

The present invention are novel 3-aminopropoxyaryl derivatives, compositions and methods of use thereof for treating congestive heart failure, coronary heart disease, or myocardial ischemia.

3-aminopropoxyaryl derivatives having cardiotonic and antihypertensive

1,2,4-Benzothiadiazine oxide derivatives of the general Formula I ##STR1## in which R.sup.1 represents an unsubstituted or substituted aryl radical;

1,2,4-benzothiadiazine oxide derivatives

The present invention provides compounds of the general formula I ##STR1## wherein R.sup.1 and R.sup.2, which are the same or different, are unsubstituted or substituted aromatic rings, Alk is a straight-chained or branched lower hydrocarbon chain and Z is a hydrogen atom, with the proviso that when Alk is a straight-chained hydrocarbon chain, Z can also be a lower alkylamino radical of the general formula II ##STR2## in which R.sup.3 and R.sup.4 are the same or different and are hydrogen atoms or straight-chained or branched lower alkyl radicals or R.sup.3 and R.sup.4, together with the nitrogen atom to which they are attached, can also form a ring optionally containing further hetero atoms; and the pharmacologically acceptable salts thereof. The present invention also provides an inventive process for preparing these compounds, as well as pharmaceutical compositions containing them. The compounds I may be used in the therapy of inflammations and they are free of gastrointestinal side effects.

2-pyrrolin-3-carbonitril-derivatives, pharmaceutical compositions

4-Thioxobenzopyrano[2,3-d]-pyrimidine derivatives of the general formulae Ia or Ib ##STR1## are described. Compounds Ia and Ib are tautomers and are valuable intermediates for the preparation of 5H-[1]-benzopyrano[2,3-d]pyrimidine derivatives having ulcer-protective action without inhibition of secretion.

4-thioxo-benzopyrano[2,3-d]pyrimidine derivatives

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Emmendingen, Germany

Hubert G Barth