Koninklijke Philips Corporation N.v.

Medtronic Bakken Research Center B.v.

Neuronexus Technologies, Inc.

Sapiens Steering Brain Stimulation B.v.

Salvia Bioelectronics B.v.

Philips Intellectual Property & Standards Gmbh

Hubert Cécile François Martens

Franciscus Paulus Maria Budzelaar

Michel Marcel Jose Decré

Pieter Gerrit Blanken

David J Anderson

Emil Toader

Erwin Rinaldo Meinders

Michel Marcel Jose Decre

Benno Tieke

Pierre Hermanus Woerlee

Jeroen Jacob Arnold Tol

Ronald Joseph Antonius Van Den Oetelaar

Daniël Willem Elisabeth Schobben

Youri Victorovitch Ponomarev

Jakob Gerrit Nijboer

Ruud Vlutters

Ahmet Ekin

Michel Gerardus Pardoel

Aaldert Jan Elevelt

Wilhelmus Robert Koppers

Judith Margreet Rensen

Cecilia Possanzini

Clemens Bos

Johan Gerard Kleibeuker

Marjolein Wilhelmina Maria Schets

Elizabeth Anne Moore

Kevin Thomas Dolan

Michel Marcel José Ghislain Decré

Hayriye Cagnan

Johannes Cornelis Koudijs

Emil-Codrut Toader

Jozef Elisabeth Franciscus Gootzen

Marco Hubertus Johannes Nijenhuis

Martin Bergtholdt

Daniel Wirtz

Heinrich Schulz

Michel Marcel Jose DecrÉ

Gerrit-Jan Bloem

Mattias Bengt Johan Åström

A mobile phone cover is provided comprising: a holderfor receiving and retaining a mobile phone, the mobile phone comprising an energy supply; a portable charging devicehaving two or more charging stations, each charging stationbeing configured and arranged for receiving and retaining a rechargeable instrument, the rechargeable instrumentcomprising an energy storage; the portable charging devicebeing further configured and arranged: to transfer energy, in use, from the energy supply of the mobile phone, placed in the holder, to the two or more charging stations; and to transfer energy, in use, from the charging stationsto the energy storage of the rechargeable instrumentplaced in the respective charging station By providing a portable charging device in a mobile phone case, there is a reduced risk that an instrument will not work properly or be inoperable. There may also be lower chance that the user will forget to take the rechargeable instruments when they are travelling and/or away from home.

Mobile phone cover comprising two or more charging stations for rechargeable instruments

A method and system are provided for determining a relation between stimulation settings for a brain stimulation probe and a corresponding V-field. The brain stimulation probe comprises multiple stimulation electrodes. The V-field is an electrical field in brain tissue surrounding the stimulation electrodes. The method comprises sequentially applying a test current to n stimulation electrodes, n being a number between 2 and the number of stimulation electrodes of the brain stimulation probe, for each test current at one of the n stimulation electrodes, measuring a resulting excitation voltage at m stimulation electrodes, m being a number between 2 and the number of stimulation electrodes of the brain stimulation probe, from the stimulation settings and the measured excitation voltages, deriving a coupling matrix, an element in the coupling matrix reflecting an amount of electrical impedance between two of the stimulation electrodes, and using the coupling matrix for determining the relation between the stimulation settings and the corresponding V-field.

Method and system for determining settings for deep brain stimulation

The invention relates to an optical storage medium comprising below an entrance face (EF) a higher recording stack (ST) comprising a higher recording layer (L) and at least a lower recording stack (ST), said lower recording stack (ST) being recorded or read back by a radiation beam () entering into the optical storage medium through the entrance face (EF) with a wavelength (&#x3bb;), focused on said lower recording stack (ST) and transmitted through the higher recording stack (ST), a recording of the higher recording layer (L) causing an optical thickness variation between recorded and unrecorded areas of said first recording layer (L), which is included into the range [0.03&#x3bb;, 0.125&#x3bb;].

Multi-stack optical storage medium

A multi-stack optical data storage medium () for recording and reading using a focused radiation beam () entering through an entrance face () of the medium () is described. It has a first substrate () with present on a side thereof a first recording stack () named L, comprising a recordable type Lrecording layer (), formed in a first Lguide groove (). A first reflective layer () is present between the first Lrecording layer () and the first substrate (). A second substrate () with present on a side thereof a second recording stack () named Lis present at a position closer to the entrance face () than the Lrecording stack () and formed in a second Lguide groove (). A transparent spacer layer () is sandwiched between the recording stacks (). The first Lguide groove () has a depth G&#x3c;100 nm. In this way a relatively high reflection value of the Lstack is achieved at a radiation beam wavelength of approximately 655 nm.

Optical data storage medium and use of such medium

A method and control system for determining and applying stimulation settings for a brain stimulation probe () is provided. The brain stimulation probe () comprises a plurality of stimulation electrodes (). The method comprises for multiple stimulation electrodes () of the plurality of stimulation electrodes (): applying a test current and determining a corresponding patient response, determining a volume of influence based () on the test current and a position of the stimulation electrode (), combining the volume of influence () and the corresponding patient response with generalized anatomic knowledge of stimulation induced behavior for associating the volume of influence () to an anatomic structure (), and determining an intersection () of the volume of influence () and the associated anatomic structure (). Then, based on the determined intersections () an optimal stimulation volume and corresponding stimulation settings for the brain stimulation probe () are determined.

A system for communicating information between at least two medical devices implanted within the body of a subject using volume conduction of electrical signals as a means of communication and wherein one of the implanted medical devices is configured to provide electrical stimulation to the tissue is disclosed. The system comprises a first implant device having at least two transmit electrodes configured to transmit electrical stimulation pulses, wherein one of the electrodes may be a common return electrode, an encoding means configured to employ a channel as a transmitter transmission medium for stimulation pulses and encoding the information into the stimulation pulses, a second implant device having at least two receive electrodes configured to receive the transmitted stimulation pulses with encoded information, and a decoding means configured to decode the information encoded into the stimulation pulses. The disclosed system provides reliable and efficient communication between implantable devices.

System and method for communicating information between implantable devices

The disclosure is directed to a deep brain stimulation (DBS) lead having a distal end for providing therapeutic electrical stimulation to tissue in a stimulation target area of a patient's brain, comprising an array of one or more stimulation elements and sensing elements located at the distal end of the lead; each of the one or more stimulation elements is capable of providing electrical stimulation to the brain tissue in the target area; and each of the one or more sensing elements is capable of detecting electrical signals produced by nerve cells within the brain; wherein after the first implantation of the lead into the brain along a trajectory that is pre-determined by non-surgical procedures, the array of stimulation and sensing elements is capable of facilitating the location of the target area and the determination for each of the stimulation elements of the required stimulation parameters needed to provide the therapeutic stimulation to the brain tissue in the stimulation target area, without requiring any additional implantations of the lead after the first implantation. A stimulation system including the DBS lead and a pulse generator is disclosed. Also disclosed is a method of providing therapeutic DBS to brain tissue using the lead.

First time right placement of a DBS lead

A system () and a method for deep brain stimulation are provided. The system () comprises a probe () and a processor (). The probe () comprises an array of sensing electrodes () for acquiring signals representing neuronal activity at corresponding positions in a brain and an array of stimulation electrodes () for applying stimulation amplitudes to corresponding brain regions. The processor () is operably coupled to the sensing electrodes () and the stimulation electrodes () and is arranged for performing the method according to the invention. The method comprises receiving () the acquired signals from the sensing electrodes (), processing () the acquired signals to find at least one brain region with atypical neuronal activity, based on the acquired signals determining () a spatial distribution of stimulation amplitudes over the array of stimulation electrodes (), and applying () the spatial distribution of stimulation amplitudes to the array of stimulation electrodes () in order to stimulate the at least one region with atypical neuronal activity.

System and method for deep brain stimulation

System for providing a stimulus comprising a probe with multiple electrodes each capable of providing a particular current to surrounding tissue a generator for providing to each of the electrodes the particular current a controller for controlling the generator to provide current to the electrodes to achieve a desired electrical field around the probe.

High resolution electrical stimulation leads

A method and a control system () are provided for determining a relation between stimulation settings for a brain stimulation probe () and a corresponding V-field. The brain stimulation probe () comprises multiple stimulation electrodes (). The V-field is an electrical field in brain tissue surrounding the stimulation electrodes (). The method comprises sequentially applying a test current to n stimulation electrodes (), n being a number between 2 and the number of stimulation electrodes () of the brain stimulation probe (), for each test current at one of the n stimulation electrodes (), measuring a resulting excitation voltage at m stimulation electrodes, m being a number between 2 and the number of stimulation electrodes () of the brain stimulation probe (), from the stimulation settings and the measured excitation voltages, deriving an (m*{acute over (&#x3b7;)}) coupling matrix, an element (q, p) in the coupling matrix reflecting an amount of electrical impedance between two of the stimulation electrodes (), and using the coupling matrix for determining the relation between the stimulation settings and the corresponding V-field.

A neuromimetic device includes a feedforward pathway and a feedback pathway. The device operates in parallel with a suspect neural region, coupled between regions afferent and efferent to the suspect region. The device can be trained to mimic the suspect region while the region is still considered functional; and then replace the region once the region is considered dysfunctional. The device may be particularly useful in treating neuromotor issues such as Parkinson's disease.

Biomimetic neurostimulation device

A system () comprising a box () for implanting in a mammal body part (), which box is provided with a first electrical contact (), and a module () for accommodating in the box, which module is provided with a second electrical contact () for cooperation with said first electrical contact. The first electrical contact and the second electrical contact are mutually movable, at least in a stationary accommodation of the module in the box, between a contact position in which said first and second electrical contacts are electrically connected, and a non-contact position in which said first and second electrical contacts are separated from each other.

System comprising a box for implanting in a body part

Growing community of inventors

Eindhoven, Netherlands

Hubert Cécile François Martens