Koninklijke Philips Corporation N.v.

Medtronic Bakken Research Center B.v.

Sapiens Steering Brain Stimulation B.v.

Salvia Bioelectronics B.v.

Sirius Medical Systems B.v.

Hubert Cecile Francois Martens

Michel Marcel Jose Decre

Wilhelmus Robert Koppers

Pierre Hermanus Woerlee

Michel Gerardus Pardoel

Franciscus Paulus Maria Budzelaar

Daniel Willem Elisabeth Schobben

Jeroen Jacob Arnold Tol

Dirk Willem Harberts

Ahmet Ekin

Benno Tieke

Ronald Joseph Antonius Van Den Oetelaar

Ke Wang

Eugenio Cantatore

Michael Marcel Jose Decre

Youri Victorovitch Ponomarev

Jakob Gerrit Nijboer

Daniel Wirtz

Heinrich Schulz

Martin Bergtholdt

Erwin Rinaldo Meinders

Johannes Leopoldus Bakx

Johannus Leopoldus Bakx

Jacobus Josephus Leijssen

Aaldert Jan Elevelt

Johannes Cornelius Antonius Muller

Stijn Willem Boere

Bram Schermers

Gerrit-jan Bloem

Johan Gerard Kleibeuker

Clemens Bos

Elizabeth Anne Moore

Kevin Thomas Dolan

Daniël Willem Elisabeth Schobben

Kevin T Dolan

Hayriye Cagnan

Judith Margeet Rensen

Ronald Van Den Oetelaar

Pierre Hermanus

Robert Alberta Arnoldus Ponsen

Johannes Cornelis Koudijs

Adrianus Cornelis Petrus Van Leijsen

Celilia Possanzini

Maartje Van Der Zalm

Marco Hubertus Johannes Nijenhuis

Michel Marcel Jose Ghislain Decre

An implantable stimulator is provided having a conformable foil-like substrate, having a longitudinal axis extending from a pulse generator to a distal end of the substrate. The substrate comprising one or more adjacent polymeric substrate layers and an electrode array. The electrode array having a first and second electrode where one or more electrical interconnections are comprised in the substrate. The conformable foil-like substrate has a maximum thickness of 0.5 millimeter or less, proximate the electrodes. By providing a more easily patternable multilayer substrate, more complicated electrode array configurations may be supported, allowing a higher degree of flexibility to address transverse and/or longitudinal misalignment. By providing a relatively thin implantable electrode array user comfort may be increased through application of energy to tissue by the implantable stimulator.

Implantable stimulator with a conformable foil-like electrode array

Implantable magnetic markers (seeds) provide a higher degree of flexibility and convenience. The magnetic field that a marker provides is determined by the magnetic properties of the materials used and the dimensions of the marker&#x2014;in general, a larger marker is easier to locate. Larger diameter markers may be used, but they should be much smaller than the average tumor size if they are to provide a useful degree of localization. An implantable magnetic marker is provided with two or more magnetic elements comprising permanent magnets connected by a mechanical connector to resiliently retain a first orientation when deployed and a second orientation before and/or during implantation. This allows complex magnetic configurations to be implanted, while retaining a simplified implantation method independent of the number of magnetic elements used. The transverse extent of the magnetic marker may be significantly reduced for implantation, allowing smaller needle diameters (smaller needle gauges) to be used or a larger number of smaller marker elements. This also allows significantly less longitudinal extents to be used. In addition, the two or more magnetic elements may be aligned to increase the transverse extent by increasing the transverse extent after implantation. This may increase detectability.

Implantable marker and a method of implanting markers

Implantable stimulator with a conformable foil like electrode array

A device for cranial implantation includes a ferrule and a plate for placement in the ferrule. Furthermore, a neurological implant system includes a probe and a device for cranial implantation.

Device for cranial implantation, and system and use thereof

A method and system are provided for visualizing a surgical path for a surgical tool. The method comprises a step of receiving anatomical information about a position of at least one anatomical structure in a region to undergo surgery, geometric information describing the surgical path and at least one safety margin defining a minimal distance between the surgical tool and the anatomical structure. The method further comprises defining a critical segment of the surgical path, in which critical segment a distance to the anatomical structure is smaller than the safety margin. Then a graphical representation of the surgical path is provided, wherein the critical segment is highlighted.

Visualizing surgical trajectories

The present invention regards a probe for deep brain stimulation (DBS), with high overall impedance, but low overall resistance. This is achieved since the probe comprises a structure comprising at least two interconnected spirals, wherein said two spirals have different direction of rotation. A system for deep brain stimulation comprising the probe, a power source and an electrode is also disclosed.

Spiraled wires in a deep-brain stimulator probe

A method of manufacturing a personalized radio frequency (RF) coil array for magnetic resonance (MR) imaging guided interventions includes: acquiring diagnostic image data reflecting the anatomy of a portion of a patient's body; planning an intervention on the basis of the diagnostic image data, wherein a field of the intervention within the patient's body portion is determined; and arranging one or more RF coils on a substrate which is adapted to the patient's anatomy, in such a manner that the signal-to-noise ratio of MR signal acquisition via the one or more RF coils from the field of the intervention is optimized.

Method of producing personalized RF coil array for MR imaging guided interventions

The invention relates to a method for determining at least one applicable path () for the movement of an object, especially of a surgical and/or diagnostical device, in human tissue () or animal tissue by means of a data set of intensity data obtained by a 3D imaging technique, the applicable path () of movement connecting a starting position () of the device with a defined target location (). According to the invention the method comprises the steps: defining the target location () of a reference point of the device and choosing at least one possible starting position of the reference point of the device; determining a candidate path of movement () between the corresponding possible starting position () and the defined target location (); and evaluating the candidate path of movement () as being an applicable path () depending on information about local intensity extrema and/or intensity variation resulting from the intensity data along the candidate path of movement (). The invention further relates to a corresponding computer-readable medium, a corresponding computer program product, and a corresponding computerized system.

Method for determining at least one applicable path of movement for an object in tissue

The present invention regards a guiding tool for neurosurgery. The guiding tool comprises subunits and a holder. The subunits are arranged in the holder so that holes for guiding a probe are created in the interface between said subunits, which allows easy release of the probe. The invention further regards a system for guiding neurosurgery probes.

Neurosurgical guiding tool

The invention relates to a probe for an implantable electro-stimulation device. The probe () has a distal end () and a proximal end (), and moreover comprises: one or more electrodes () a shield () of conducting material covering a major part of the probe, said shield extending from the vicinity of at least one of the one or more electrodes () towards the proximal end () or towards the distal end () of the probe (); and a layer () of insulating material covering part of the shield () in the vicinity of the at least one of the one or more electrodes. The shield protects wires (), extending from electrodes to the proximal end of the probe, from undesired interference of external RF fields. The exposed part of the shield not covered by the layer of insulating material serves as a return electrode for the electrostimulation signal path.

Probe for implantable electro-stimulation device

A stimulation apparatus includes a stimulation lead (), a multiplexer (), a stimulation signal generator (), and a signal detector (). The stimulation lead () includes a plurality of stimulation electrodes () disposed in an array about a distal portion of the lead body (). The arrangement of the electrodes () facilitates the controlled steering of stimulating electrical field () in three dimensions. Four dimensional field steering may also be provided.

Tissue stimulation method and apparatus

The disclosure is directed to a deep brain stimulation (DBS) lead having a distal end for providing therapeutic electrical stimulation to tissue in a stimulation target area of a patient's brain, comprising an array of one or more stimulation elements and sensing elements located at the distal end of the lead. After the first implantation of the lead into the brain along a trajectory that is pre-determined by non-surgical procedures, the array of stimulation and sensing elements is capable of facilitating the location of the target area and the determination for each of the stimulation elements of the required stimulation parameters needed to provide the therapeutic stimulation to the brain tissue in the stimulation target area, without requiring any additional implantations of the lead after the first implantation.

First time right placement of a DBS lead

A method for determining an applicable path of movement of an object in human or animal tissue is based on intensity data obtained by a 3D imaging technique. The applicable path of movement connects a starling position of the object with a defined target location. The method includes defining the target location of a reference point of the object and choosing at least one possible starting position of the reference point of the object. Further, the method includes determining a candidate path of movement between the corresponding possible starling position and the defined target location. Next, the candidate path of movement is evaluated for being an applicable path. The candidate path is evaluated based on information about local intensity extrema and/or intensity variation resulting from the intensity data along the candidate path of movement.

The invention relates to an electronic apparatus () comprising a charging module () for receiving external energy (RF) and for transferring it to a rechargeable energy storage () in a 'charging state'. Moreover, the apparatus comprises a processing module which can be operated in a working state that is enabled if the charging module () is in the charging state and the apparatus is in a standard operating mode. The processing module may for example be a communication module () that can communicate wirelessly in its working state. In the standard operating mode, communication with the apparatus () is thus only possible if the apparatus () is simultaneously charged. The communication module () can therefore be completely switched off during the residual time, thus reducing power consumption and avoiding erroneous communication or misuse.

Apparatus with wireless communication module

A method is provided for determining a threshold () for spike () detection in an electrophysiological signal (). The method comprises a step of determining an estimated envelope () of the electrophysiological signal (), a step of, based on the estimated envelope (), determining an estimated Gaussian noise, a step of determining a distribution () of instantaneous amplitudes of the estimated Gaussian noise, a step of determining a mode () of the distribution () of instantaneous amplitudes, and determining the threshold () based on the mode () of the distribution () of instantaneous amplitudes.

Method and system for determining a threshold for spike detection of electrophysiological signals

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Eindhoven, Netherlands

Hubert Cecile Francois Martens