University of California

The United States Government As Represented by the Department of Veterans Affairs

The J. David Gladstone Institutes

Hubert C Chen

Robert V Farese, Jr

Sylvaine Cases

Steven J Smith

Sandra K Erickson

Methods and compositions for modulating carbohydrate metabolism in a host are provided. In the subject methods, diacylglycerol acyltransferase (DGAT) activity (specifically DGAT1 activity) is modulated, e.g., reduced or enhanced, to achieve a desired insulin and/or leptin sensitivity, thereby modulating carbohydrate metabolism, e.g., increasing or decreasing blood glucose levels, glucose uptake into cells and assimilation into glycogen. Also provided are pharmaceutical compositions for practicing the subject methods. The subject methods and compositions find use in a variety of applications, including the treatment of hosts suffering conditions associated with abnormal carbohydrate metabolism, such as obesity or diabetes.

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Newbury Park, CA, United States of America

Hubert C Chen