Boehringer Mannheim Gmbh

Roche Diagnostics Gmbh

Hubert Bayer

Christoph Seidel

Hans Georg Ihlenfeldt

G&uuml;nther Gerhard Jung

Ursula Henrike Wienhues

Gertraud Ehrlich-Weinreich

Christian Klein

Erhard Kopetzki

Ursula-Henrike Wienhues

Heiner Vonwirth

Michael Marschall

Novel HCV peptide antigens are described representing partial sequences of the C-100-3 and env/core with C-regions. These peptide antigens are suitable for the determination of HCV antibodies as immunogens for the production of antibodies against HCV and as vaccines for the production of vaccines against HCV.

HCV peptide antigens and methods for the determination of HCV

New HCV peptide antigens are described. These peptide antigens are suitable for the determination of HCV antibodies as immunogens for the preparation of antibodies to HCV and as immunogens for the preparation of vaccines to HCV.

HCV peptide antigens and method of determining HCV

The invention concerns a virus solution which contains a detergent having the general formula I and serves to stabilize the virus solution as well as its production and use in heterogeneous immunoassays for the detection of antibodies against viruses.

Virus solution for use in immunoassays

A fusion protein with at least one antigenic and/or immunogenic determinant from the env, gag and/or pol region of HIV1 and/or HIV2 which contains the tetrapeptide sequence NH.sub.2 -Met-Tyr-Tyr-Leu as the N-terminal component as well as a process for its production and use.

Expression of HIV1 and HIV2 polypeptides and their use

The invention relates to a method for determining HIV (human immunodeficiency virus) specific antibodies. A sample is incubated with a solid phase, to which streptavidin is bound in a way to make 0.1-2.5 .mu.g streptavidin per ml of reaction volume available for binding, a biotinylated polypeptide, and a labelled receptor which binds to HIV specific antibodies. The biotinylated polypeptide contains at least one of the amino acid sequences ##STR1## and is from 7 to 50 amino acids long. Following complex formation onto the solid phase, solid and liquid phase are separated, and label is measured in one of these.

Growing community of inventors

Weilheim, Germany

Hubert Bayer