Hoechst Aktiengesellschaft

Schott Glaswerke

Hubert Bader

Axel Walch

Diether Ruppel

Michael Magerstadt

Merten Schlingmann

Kurt Nattermann

Hans-Ullrich Hoppe

Dieter Ulschneider

A cofactor having an aromatic or benzylic amino group is converted into an isothiocyanate by reaction with a compound such as thiophosgene and the isothiocyanate of the cofactor is attached to a polymer which is preferably water-soluble. When the polymer has amino groups, a thiourea bridge is formed between the polymer and cofactor and a polymer having hydroxyl groups results in a thiocarbamate bridge. The polymer may be a copolymer of vinylamine or vinylmethylamine and vinylmethylacetamide, partially alkylamine-substituted .alpha., .beta.-poly-(2-hydroxyethyl)-D,L-aspartamide, polyethyleneimine or carbohydrate. The cofactor bound to a polymer and an enzyme are contained in microcapsules or in a membrane to form an enzyme reactor.

Immobilization of an isethiacyanate of a cofactor on a polymer

The invention relates to biodegradable poly((hydroxyalkyl)amino dicarboxylic acid) derivatives of the formula I ##STR1## in which n, m, x, y, z, R and R' have the indicated meanings, and to a process for their preparation and to the use thereof for depot formulations with controlled delivery of active ingredient.

Biodegradable poly(hydroxyalkyl)amino dicarboxylic acid) derivatives, a

A stepped-index optical fiber is disclosed for transmission of high-power radiation, especially laser, radiation, which fiber is capable of transmitting radiation without substantially impairment of the beam quality (of the beam product), can be bent with a specific radius, and wherein the cross-sectional area of the beam on the input coupling surface of the fiber can be very large. Formulae are presented for calculating the dimensions of the fiber.

Stepped-index optical fiber for transmission of high-power laser

Polyamides in which amino acids are incorporated in the polymer backbone via two amino or carboxyl groups and which carry in the .alpha.-position to the amide structure a functional group which is responsible for degradation and active compound release are highly suitable for the preparation of biologically degradable active compound depot preparations having controlled release of the active compound.

Growing community of inventors

Mainz, Germany

Hubert Bader