Novartis Ag

Huanqing Jia

Zhongbo Fei

Jianhua Wang

Wei Zhang

Zhongcheng Min

Hao Zhang

Hui Wang

Xiaohui Lin

Wei Li

Huangchao Yu

The present invention relates to a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein LG, A, n, m and p are as defined in the Summary of the Invention, said manufacture including the manufacture and use of a compound of the formula VI; wherein Ris a secondary amino protecting group and Ris unsubstituted or substituted alkyl, unsubstituted or substituted cycloalkyl or unsubstituted or substituted aryl.

Manufacture of compounds and compositions for inhibiting the activity of SHP2

The present invention relates to a method for the manufacture of a compound of Formula I or a pharmaceutically acceptable salt, acid co-crystal, hydrate or other solvate thereof, said method comprising reacting a compound of the formula II with a compound of the formula III according to the following reaction scheme: wherein LG, A, n, m and p are as defined in the Summary of the Invention.

Growing community of inventors

Changshu, China

Huanqing Jia