Bgi Tech Solutions Co., Ltd

Bgi Shenzhen

Bgi-shenzhen Co., Limited

Bgi Genomics Co., Limited

Bgi Diagnosis Co., Ltd.

Huanming Yang

Jun Wang

Jian Wang

Yun Wang

Xiao Liu

Yong Qiu

Xiuqing Zhang

Xun Xu

Fei Gao

Bo Wen

Fang Zhou Chen

Qiang Feng

Xiaoyu Liu

Himanshu Sethi

Peng Zeng

Yanyan Zhang

Yan Ping Ren

Dongya Zhang

Junjie Qin

Junwen Wang

Shengpei Chen

Junjie Zhang

Yue Shen

Fang Chen

Huaiqian Xu

Zhuye Jie

Suisha Liang

Xuyang Yin

Yingrui Li

Shihong Chen

Weiwei Xie

Li Bao

Hanjie Wu

Dennis G Ballinger

Hui Jiang

Chunlei Zhang

Xiaoyu Pan

Tai Chen

Xuchao Li

Ruifang Zhang

Siqi Liu

Longying Liu

Weiming He

Shancen Zhao

Xuemei Zhang

Shenghui Li

Haiyi Zhao

Dahai Jiang

Jin Zi

Yulai Guo

Zheng Su

Jing Zheng

Vladimir I Bashkirov

Jianfeng Zhu

Xiaodong Fang

Peixiang Ni

Lifu Liu

Shang Yi

Huijuan Ge

Disclosed are a method and a system for determining genome copy number variation, which relates to the technical field of bioinformatics. The method and the system have clinical feasibility, and can precisely detect a micro-deletion/micro-duplication area of 0.5 M under the situation of using data of about 50 M.

Method and system for determining copy number variation

A method for encoding and storing text information using DNA as a storage medium, a decoding method therefor and an application thereof. The method for using DNA to store text information comprises: encoding characters into computer binary digits by means of encoding, and converting the binary digits into DNA sequences by means of transcoding; and artificially synthesizing the DNA sequences encoded with character information, positioning the characters by means of a designed ligation adapter, and assembling the DNA sequences encoded with the character information according to a pre-set order. The method for using DNA to store text information has the advantages of a small storage volume, a large storage capacity, a strong stability and low maintenance costs.

Method for using DNA to store text information, decoding method therefor and application thereof

Provided is a parental genome assembly method, comprising: using the sequencing data of parental selfing line progeny population to assemble and perfect the parental genome data. Also provided is a device for implementing the method.

Parental genome assembly method

Biomarkers for diabetes and usages thereof are provided. And the biomarkers are nucleotides having polynucleotide sequences defined in SEQ ID NOs: 1-50.

Biomarkers for diabetes and usages thereof

The present invention relates to a method for quantifying the relative content of a protein in a sample. The present invention also relates to a method for comprising the relative content of a protein in at least two samples.

Method for quantification of proteome

A method for detecting hydroxymethylation modification in nucleic acid comprises: glycosylating the nucleic acid, digesting with MspI, ligating the digested fragments to a biotin-labeled linker at both ends thereof, digesting with NlaIII; capturing the digested fragments using streptavidin magnetic beads to produce fragments having the biotin-labeled linker at one end and a CATG 4-base sticky end at the other end, wherein these fragments reveal modification information of their adjacent CCGG sites; ligating the CATG sticky end to a linker containing a recognition site of MmeI or Ecop15I, digesting with corresponding restriction endonuclease to produce short sequence fragments that can reveal modification information of their adjacent CCGG sites; and performing a tag number comparison to obtain information about methylation and hydroxymethylation modification relative levels. A use of the method is also provided.

Method for detecting hydroxylmethylation modification in nucleic acid and use thereof

A method for analyzing a genome of a single cell is provided, and a kit is also provided. The method for analyzing the genome of the single cell may comprise separating and lysing the single cell to obtain a whole-genome DNA of the cell; subjecting the whole-genome DNA to a whole-genome amplification to obtain a whole-genome amplification product; performing a PCR amplification using the whole-genome amplification product as template and using housekeeping-gene-specific primers to detect the housekeeping gene of the whole-genome amplification product; and determining whether the whole genome amplification product meets a requirement for sequencing based on the detection result, wherein a uniform distribution of the amplification product in each chromosome is an indication of the amplification product meeting the requirement for sequencing.

Method for single cell genome analysis and kit therefor

The present invention provides an error correcting method of test sequence, which involves receiving test sequences, configuring high frequency short string list based on a preset high frequency threshold value, traversing each received test sequence, searching an area with the largest number of continuous high frequency short strings on each test sequence in combination with high frequency short string list, configuring whole left sequence and/or right sequence of high frequency short strings at left side and/or right side of searched area according to corresponding received test sequence and high frequency short string list, and constituting corresponding test sequence according to configured left and/or right sequence and searched area. The present invention also provides corresponding error correcting system of test sequence and gene assembly equipment.

Error correcting method of test sequence, corresponding system and gene assembly equipment

Growing community of inventors

Shenzhen, China

Huanming Yang