University System of Maryland

American Dental Association Health Foundation

American Dental Association Foundation

Ada Foundation

Huakun Xu

Frederick C Eichmiller

Michael D Weir

Laurence C Chow

Shozo Takagi

Limin Sun

Gary E Schumacher

Ling Zhang

The present invention provides rechargeable dental materials that can be widely applied in a variety of dental applications. The rechargeable dental materials of the invention may be included in dental primers, dental adhesives, dental resins, dental composites, dental bonding systems and the like, as well as dental cements, dental sealants, dental bases and dental liners, each of which is rechargeable with calcium and phosphate ions. The present invention also provides for a method of recharging the rechargeable dental material with calcium and phosphate ions.

Rechargeable calcium phosphate-containing dental materials

The present invention provides dental bonding agents and dental bonding systems comprising the dental bonding agents. The dental bonding agents of the invention are characterized by having antibacterial properties, and in some aspects of the invention, remineralizing properties.

Nanostructured antibacterial and remineralizing dental bonding agents and dental bonding systems

The invention provides injectable, biofunctional agent-containing calcium phosphate cement bone pastes for bone tissue engineering, and methods of making and using the same.

Bone pastes comprising biofunctionalized calcium phosphate cements with enhanced cell functions for bone repair

Described herein are dental composites comprising amorphous calcium phosphate nanoparticles and methods of making and using the same. The dental composites display increased Ca and POrelease, improved mechanical properties, and improved antibacterial properties. Anti-bacterial agents, such as quaternary ammonium salts or silver-containing nanoparticles may be included in the composites.

Dental composites comprising nanoparticles of amorphous calcium phosphate

Living cellular material is encapsulated or placed in a protective material (cell protector) which is biocompatible, biodegradable and has a three-dimensional form. The three dimensional form is incorporated into a matrix that maybe implanted in vivo, ultimately degrade and thereby by replaced by living cell generated material.

Three dimensional cell protector/pore architecture formation for bone and tissue constructs

Combining nanosized particles of a source of desired dental restorative, repair or therapeutic materials with strengthening agents in various generally nanosized form such as whiskers, fibers, particles and the like in a resin matrix provides a highly strain resistant composite which more effectively releases the therapeutic agents. The utilization of nano sized particles of the therapeutic agent in the combination enables observation of significantly improved therapeutic results.

Dental releasing materials

A bone replacement material and therapy comprises the combination of calcium phosphate compounds and two or more soluble fillers in the form of fibers, mesh or other materials which have the dual functions of reinforcing an in vivo implant while dissolving at a programmed rate to form macropores capable of receiving natural bone ingrowth.

Self-hardening calcium phosphate materials with high resistance to fracture, controlled strength histories and tailored macropore formation rates

Continuous fibers, resin-fiber pastes, or continuous fiber-reinforced preforms are inserted into tooth cavities to form high-strength dental restorations. The fibers may be mixed or coated with a resin monomer and may be used with fillers such as fluoride-releasing fillers and colorants. The resin-fiber mixture may be hardened into preforms suitable for inserting into tooth cavities. Conventional filling materials such as composite resins and glass ionomers may be used to complete the restoration. Other applications include endodontic posts, retention pins, provisional restorations, and indirect restorations. Fiber reinforcement results in strength, toughness and elastic modulus (stiffness) several times greater than those of currently available direct-filling composite resins. The fiber performs are easily handled and placed into tooth cavities; the restorations are aesthetic and wear compatible, and release fluoride. The final restoration has significantly reduced polymerization shrinkage because the fiber preform can be pre-hardened and therefore will shrink little during hardening of the final restoration.

Continuous fiber-reinforced dental restorations

A composition useful as a restorative material includes a curable matrix with whiskers which preferably have a silicon dioxide containing coating thereon that are then silanized and may also include optional particulate filler of the type which may release fluorides. The polymeric matrix bonds more tightly to the whiskers due to the coating of silicon dioxide on the surface of the whiskers and the coaction between said silicon dioxide and the silane compound. Particles adhered to the whisker also enhance the mechanical properties by virtue of the whisker's surface being thereby roughened. A method of manufacture is also disclosed.

Growing community of inventors

Frederick, MD, United States of America

Huakun Xu