Waters Technologies Corporation

Hua Yang

Edouard S P Bouvier

Moon Chul Jung

Kevin Daniel Wyndham

Wade P Leveille

Raymond P Fisk

Jonathan L Belanger

Mathew H DeLano

Hillary B Hewitson

Steven A Cohen

Edouard SP Bouvier

Exemplary embodiments are directed to devices for separating a sample by chromatography, components of the devices, and methods for using the devices, and directed to devices and components for use with immobilized enzymatic reactors. A device includes a wall having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the wall includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %. A component includes a body having a wetted surface exposed to a mobile phase including the sample during chromatographic separation. The wetted surface of the body includes an alloy material including the following constituents: nickel, and cobalt and/or chromium where the alloy is limited in an amount of titanium to 1 wt %.

Nickel-cobalt alloy material devices and components

Embodiments of the present invention are directed to a porous monolith polymeric composition having utility in catalysis, chromatography, filtration, and electro-kinetic pumps, devices incorporating such composition and methods or making and using such monoliths. The monoliths are characterized by a substantially homogeneous skeletal core with little shrinkage, few voids and few channels.

Porous material and devices for performing separations, filtrations, and catalysis and EK pumps, and methods of making and using the same

Embodiments of the present invention are directed to a porous monolith polymeric composition having utility in catalysis, chromatography, filtration, and electro-kinetic pumps, devices incorporating such composition and methods of making and using such monoliths. In some embodiments the monoliths can include a skeletal core having a substantially homogeneous polymeric composition of two or more organic silane monomers and pores that define an interstitial volume in the skeletal core. The pores can include macropores and less than 5% of the interstitial volume can be mesopores. Such monoliths can, in some embodiments, be disposed in a housing having at least one wall that defines a chamber such that all fluid flowing into the chamber passes through the pores of the monolith.

High-pressure electrokinetic ('EK') pumps comprising a hybrid monolith provide a high surface charge density and a continuous stable skeleton morphology with micrometer-sized through-pores. The hybrid monolith of the subject invention has superior mechanical strength and better stability in comparison to prior art monoliths with equivalent mechanical stability. The surface charge of the hybrid monolith can be modified and/or made stable by the use of different chemical reagents. The chemical reagents and resulting modification to the monolith serves to expand the usefulness of the hybrid monolith to a variety of pumping applications including chip-based systems and other applications where the ability to pump an acidic solution is required.

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Franklin, MA, United States of America

Hua Yang