Astrazeneca Ab

Neomed Institute

Hua Yang

Christopher Walpole

Daniel Pagé

Ziping Liu

Maxime Tremblay

William Brown

Yun-Xing Cheng

Zhongyong Wei

Miroslaw Jerzy Tomaszewski

Zena Qadoumi

Sanjay Srivastava

Zhong-yong Wei

Regis Dolaine

Daniel Page

Compounds of Formula (I) or pharmaceutically acceptable salts thereof; wherein R, R, R, and Rare as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain. 

Benzimidazole derivatives, compositions containing them, preparation thereof and uses thereof

Compounds of formula I or pharmaceutically acceptable salts thereof: wherein R, R, Rand Rare as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Therapeutic compounds

Compounds of Formula I, or pharmaceutically acceptable salts thereof: wherein R, R, R, R, R, and G are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain.

Compounds, compositions containing them, preparation thereof and uses thereof I

Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R, R, R, Rand Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain. 

Compounds of formula (I) or pharmaceutically acceptable salts thereof: wherein R1, R2, R3, R4 and Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain. 

Compounds of formula (I) wherein R, R, Z, R, R, Ar, X and Y are as defined in the specification as well as salts and pharmaceutical compositions including the compounds were prepared. These compounds are useful in therapy, in particular in the management of pain. 

Compounds

Compounds of formula I or pharmaceutically acceptable salts thereof Formula (I) wherein Ar, R, R, R, R, Rand X are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain 

Azaindole derivatives, preparations thereof, uses thereof and compositions containing them

Compounds of formula (I) or pharmaceutically acceptable salts thereof: Formula (I) wherein R, R, RF, RFand Z are as defined in the specification as well as salts and pharmaceutical compositions including the compounds are prepared. They are useful in therapy, in particular in the management of pain 

Compounds of general formula (I), are disclosed and claimed in the present application, as well as salts and pharmaceutical compositions comprising the novel compounds and their use in therapy, in particular in the management of pain

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Montreal, Canada

Hua Yang