Lifecell Corporation

Hua Wan

Hui Xu

Wenquan Sun

Rick T Owens

Li Ting Huang

Yi Heng Chen

Dennis Lee

Kai-Roy Wang

Nathaniel Bachrach

Nimesh Kabaria

Ming F Pomerleau

Sean Collins

Patrick Leamy

I-Chien Liao

Yi Chen

Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating select portions of a tissue matrix with a fluid containing at least one agent to produce a tissue matrix with variable mechanical and/or biological properties.

Methods for localized modification of tissue products

Disclosed herein are muscle implants and methods of making muscle implants comprising one or more decellularized muscle matrices. The muscle matrices can, optionally, be joined to one or more decellularized dermal matrices. The muscle implants can be used to enhance muscle volume or to treat muscle damage, defects, and/or disorders. The decellularized muscle matrices in the implants retain at least some of the myofibers found in a muscle tissue prior to processing.

Decellularized muscle matrix

Methods of forming a composition for treatment, compositions for treatment, and methods of treatment with the compositions are provided. The methods can include coating a synthetic material substrate with a biologic material. A portion of the biologic material can be acid-swelled.

Mesh compositions and methods of production

Tissue fillers derived from decellularized tissues are provided. The tissue fillers can include acellular tissue matrices that have reduced inflammatory responses when implanted in a body. Also provided are methods of making and therapeutic uses for the tissue fillers.

Natural tissue scaffolds as tissue fillers

Tissue products lacking a desired percentage of immunogenic epitopes, such as galactose alpha-1,3 galactose epitopes, are provided. Methods of making and using the tissue products are also provided.

Methods of removing alpha-galactose

A tissue-derived hydrogel, as well as methods of making and using such hydrogels, are provided.

Elastic tissue matrix derived hydrogel

Methods for treating tissue matrices and tissue matrices produced according to the methods are provided. The methods can include treating a tissue matrix with a proteolytic enzyme to produce a desired pliability of the tissue matrix and/or to control the immunogenicity of the tissue matrix. The methods can also comprise performing an assay to determine if contacting the at least one collagen-containing tissue matrix with a proteolytic enzyme has altered the at least one collagen-containing tissue matrix to reduce a human immune response to the tissue matrix.

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Princeton, NJ, United States of America

Hua Wan