Purdue Pharma L.p.

Euro-Celtique S.a.

Hua-Pin Huang

Benjamin Oshlack

John K Masselink

Alfred P Tonelli

Mark Chasin

Paul D Goldenheim

Rampurna Gullapalli

David Sackler

Glenn Van Buskirk

Vijay Vashi

Meredith Machonis

Richard Mannion

Philip Goliber

A solid oral controlled-release oral dosage form of hydrocodone is disclosed. The dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and a sufficient amount of a controlled release material to render the dosage form suitable for twice-a-day administration to a human patient, the dosage form providing a C/Cratio of 0.55 to 0.85, said dosage form providing a therapeutic effect for at least about 12 hours.

Controlled release hydrocodone formulations

Disclosed in certain embodiments is a dosage form comprising a plurality of extruded particles comprising an adverse agent or antagonist and a layer disposed about the particles.

Pharmaceutical products

Methods of manufacturing oral dosage forms

The present invention relates to co-extruded pharmaceutical compositions and dosage forms comprising an adverse agent, such as an opioid antagonist, which can be sequestered. The pharmaceutical compositions and dosage forms diversion of a dosage form containing an active pharmaceutical agent, such as an opioid. The present invention also relates to methods of treating a patient with such a dosage form, as well as kits containing such a dosage form with instructions for using the dosage form to treat a patient. The present invention further relates to a process for the preparation of such pharmaceutical compositions and dosage forms comprising co-extrusion of a core comprising an adverse agent and a sheath.

Tamper resistant dosage form comprising co-extruded, adverse agent particles and process of making same

A solid oral controlled-release dosage form of hydrocodone is disclosed, the dosage form comprising an analgesically effective amount of hydrocodone or a pharmaceutically acceptable salt thereof, and controlled release material.

Methods of manufacturing oral formulations

Methods of providing analgesia

Tamper resistant dosage form comprising co-extruded, sequestered adverse agent particles and process of making same

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Englewood Cliffs, NJ, United States of America

Hua-Pin Huang