Crage Medical Co., Limited

Jecho Laboratories Inc.

Carsgen Therapeutics Limited

Koninklijke Philips Corporation N.v.

National Oilwell Varco, L.p.

Shanghai Jiao Tong University

China Unionpay Co., Ltd.

Shanghai Zhenhua Heavy Industries Company Limited

Shanghai Cancer Institute

Shanghai Eternal Machinery Co., Ltd.

Carsgen Therapeutics Co., Ltd.

Cafa Therapeutics Limited

State Grid Corporation of China

Petrochina Company Limited

Jiangsu Electric Power Company

Hua Jiang

Zonghai Li

Huamao Wang

Peng Wang

Huiping Gao

Bizhi Shi

Lei Han

Junsheng Chen

Jing Wang

Jianren Gu

Shengli Yang

Jianwei Zhu

Huili Lu

Yueqing Xie

Lei Zhang

Jian Zhang

Gang Wang

Qi Zhou

Steven Broeils Luitjens

Qingyu Huang

Robert Benjamin Donnally

Bin Dong

Jozef Pieter Van Gassel

Sishuang Wan

Fangzhong Shen

Weiqi Yu

Gilein De Nijs

Jiawen Tu

Hongyang Wang

Zhimin Shi

Xiaohan She

Juan Kong

Fuquan Chen

Kai Ding

Baohong Zhang

Kesang Li

Cedric Cagliero

Manyu Luo

Huifang Zong

Hong Luo

Xusen Yang

Xiongyu Wang

Daniel Bernard Cugnoni

Yunfu Yan

Linlin Yang

Haiwei Zhang

Lan Liu

Xian Guo

Andrew Burnette

Suyun Hu

Tongshan Wang

Wei Liu

Shuyuan Shi

Qingchun Jiang

Zhaohui Xu

Yongxin Li

Jun Zhu

Xi Wu

Zheng Wang

Disclosed in the present invention is a genetically engineered cell, expressing an exogenous receptor that specifically binds to a target antigen and exogenous CCL21, and capable of further expressing an IL-7R binding protein or exogenous IL-7 that promotes cell proliferation. Also disclosed are an expression construct comprising an exogenous CCL21 expression cassette, and a vector containing same, a virus, and a pharmaceutical composition comprising said cell. Also disclosed is an application for the cell, the expression construct, the vector, and the virus in the preparation of drugs for inhibiting tumours or inhibiting pathogens.

Genetically engineered cell and application thereof

The present invention relates to an automatic image positioning system for a sheet material. The automatic positioning system is used to convey the sheet material from a feeding place to a paper gripper bar. The automatic positioning system includes a first conveying device and a second conveying device, the automatic positioning system further includes a photoelectric detection device used to perform positioning and positioning correction on the sheet material, and the photoelectric detection device is provided at a starting end of the second conveying device (). Compared with the prior art, the present invention utilizes an photoelectric detection device to perform positioning and positioning correction on a material, uses a vacuum adsorption component to stabilize the material, and has advantages of high systemic positioning accuracy, high positioning correction accuracy, and strong material adaptability.

Automatic image positioning system for sheet material

A polypeptide composition, and methods of making the same, may include a first polypeptide and a second polypeptide, wherein the first polypeptide comprise a first toxin fragment and a first intein fragment, the second polypeptide comprise a second toxin fragment and a second intein fragment, the first polypeptide is different from the second polypeptide; the first toxin fragment and the second toxin fragment are non-biotoxic; the first polypeptide and the second polypeptide may make the first toxin fragment and the second toxin fragment into biotoxic toxins by an interaction of the first intein fragment and the second intein fragment. Kits may include such first and second polypeptides, and such compositions and kits may be used in treating tumors.

Polypeptide composition

A method, apparatus, device and storage medium for verifying a real store, which belong to the field of data processing. The method includes: acquiring inputted store information of a first store (S); searching for, based on the store name and the store address of the first store, a first target store name in a first target area in an electronic map () searching for, based on the store address of the first store, a real store address database, and the store name of the first store, a second target store name in a second target area in the electronic map (S) determining, under a condition that the first target store name or the second target store name exists, that the first store is a real store (S).

Method, apparatus, device and storage medium for verifying real store

Provided is a polypeptide combination, a targeting component thereof comprising a shielding peptide, a cleavable part, an antigen-binding part and a first intein fragment, the shielding peptide and the antigen-binding part being connected by means of the cleavable part, and the antigen-binding part being directly or indirectly connected to the first intein fragment; a toxin component thereof comprises a second intein fragment and a toxin, and the second intein fragment is directly or indirectly connected to the toxin; the targeting component and the toxin component form an immunoconjugate by means of the interactive action between the first intein fragment and the second intein fragment; in the immunoconjugate, the shielding peptide and the antigen-binding part are connected by means of the cleavable part, and the antigen-binding part is connected to the toxin. Also provided are a preparation method and a pharmaceutical use for the polypeptide combination.

Polypeptide combination used for tumour immunotherapy, and preparation method therefor

Disclosed herein are methods of treating a subject exhibiting a solid tumor that expresses Glypican-3 (GPC3). The methods typically utilize g GPC3 chimeric antigen receptor immunoresponsive cells to a subject in need thereof to effect killing of tumor cells.

Compositions and methods of cellular immunotherapy

The present disclosure discloses a method for expressing and preparing a bivalent bispecific antibody. In the present disclosure, each portion of a bivalent bispecific antibody and an immune hybrid protein thereof is respectively expressed in a suitable prokaryotic or eukaryotic cell system, separated and purified by high-performance affinity chromatography, and then spliced in vitro by trans-splicing reaction mediated by an intein, to prepare the bivalent specific antibody and an immune hybrid protein thereof.

Bivalent bispecific antibody hybrid protein expression and preparation methods

Provided in the present invention are a specific antibody of BCMA and a BCMA-targeting immune effector cell, and also provided are a chimeric antigen receptor-modified T cell prepared using the antibody and the use thereof.

BCMA-targeting antibody and use thereof

Disclosed herein are methods of treating a subject exhibiting a cell that expresses Wilms tumor protein 1 (WT1). The methods typically utilize anti-WT1 antigen binding units or chimeric antigen receptor immunoresponsive cells to a subject in need thereof to effect killing of tumor cells.

Methods for preparing a recombinant protein from a bacterium are provided. The method includes constructing an expression vector including two promoters. Each of the two promoters attaches a secretion signal peptide to one polypeptide of a protein. The protein attached with the two promoters and secretion signal peptides is then cloned into the expression vector to provide a recombinant expression plasmid. The recombinant expression plasmid is transformed into a host cell. A fermentation process is performed to grow the host cell and to induce an expression to synthesize polypeptides in the host cell and to transport the polypeptides to an outside of a cytoplasm of the host cell, such that the polypeptides are released in a soluble form in a growth medium of the host cell. The polypeptides are assembled into a three-dimensional structure of the protein. The protein is captured from the growth medium.

Method for preparing recombinant protein from bacterium and composition containing the same

Provided in the present invention is an antibody for anti-claudin 18A2 and an immune effector cell targeting claudin 18A2. Also provided are methods for inducing cell death and treating tumours.

Antibody for anti-claudin 18A2 and use thereof

A mast erection system includes a first mast erection apparatus that is adapted to pivotably raise a drilling rig mast of a drilling rig assembly to an intermediate raised position wherein the drilling rig mast is oriented at a first acute angle relative to a horizontal plane, and a second mast erection apparatus that is adapted to further pivotably raise the drilling rig mast from the intermediate raised position at the first acute angle to a fully raised position wherein the drilling rig mast is oriented at a second angle relative to the horizontal plane that is greater than the first acute angle.

Systems and methods for raising drilling rig assemblies

A nucleic acid encoding a chimeric antigen receptor expressed at surface of a T lymphocyte, said chimeric antigen receptor comprises, connected in the order of, an extracellular binding domain, a transmembrane region, and an intracellular signaling domain, wherein the extracellular binding domain comprises a single chain antibody, scFv(GPC3), which specifically recognizes the C-terminal epitope of GPC3. A genetically modified T lymphocyte having a chimeric antigen receptor expressed at surface thereof, and the chimeric antigen receptor is expressed by the nucleic acid described above.

Chimeric antigen receptors targeting GPC3 and uses thereof

A nucleic acid for coding a chimeric antigen receptor protein expressed on the surface of a human T lymphocyte. The chimeric antigen receptor protein comprises an extracellular binding domain, a transmembrane domain and an intracellular signal domain that are orderly connected. The extracellular binding domain comprises a single-chain antibody scFv (EGFR) for specific recognition of 287to 302amino acid epitopes of a human epidermal growth factor receptor (EGFR).

Nucleic acids encoding chimeric antigen receptor proteins which bind epidermal growth factor receptor and T lymphocyte expressing the protein

Multi-functional antibody polypeptide comprises:

Multi-functional antibody polypeptide for cryptic epitope of epidermal growth factor receptor and T cell antigen

Growing community of inventors

Shanghai, China

Hua Jiang